4-(4-nitrobenzoyl)-8-(pyridin-3-ylmethyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>thiazepine

Base Information

Chemical Name:4-(4-nitrobenzoyl)-8-(pyridin-3-ylmethyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>thiazepine
CAS No.:186808-52-6
Molecular Formula:C₂₀H₁₈N₄O₃S
Molecular Weight:394.454
Hs Code.:

Synonyms:4-(4-nitrobenzoyl)-8-(pyridin-3-ylmethyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>thiazepine

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Chemical Property of 4-(4-nitrobenzoyl)-8-(pyridin-3-ylmethyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>thiazepine

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Technology Process of 4-(4-nitrobenzoyl)-8-(pyridin-3-ylmethyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>thiazepine

There total 6 articles about 4-(4-nitrobenzoyl)-8-(pyridin-3-ylmethyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>thiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 6959-48-4
3-chloromethylpyridinium chloride

: 186808-51-5
4-(4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>diazepine

: 186808-52-6
4-(4-nitrobenzoyl)-8-(pyridin-3-ylmethyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>thiazepine

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 120 ℃; for 20h;
DOI:10.3987/COM-98-8179

Reference yield:

: 3099-31-8
nicotinyl chloride

: 186808-51-5
4-(4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>diazepine

: 186808-52-6
4-(4-nitrobenzoyl)-8-(pyridin-3-ylmethyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>thiazepine

Guidance literature:: With potassium carbonate; potassium iodide;
DOI:10.1021/jm030287l

Reference yield:

: 213678-61-6
5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>diazepine

: 186808-52-6
4-(4-nitrobenzoyl)-8-(pyridin-3-ylmethyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>thiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

2: 19 percent / K₂CO₃, KI / dimethylformamide / 20 h / 120 °C

With potassium carbonate; triethylamine; potassium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-98-8179