(E)-4-(3,3-dimethyl-but-1-E-en-1-yl)-3,5-bis(4-hydroxyphenyl )isoxazole

Base Information

Chemical Name:(E)-4-(3,3-dimethyl-but-1-E-en-1-yl)-3,5-bis(4-hydroxyphenyl )isoxazole
CAS No.:1400414-32-5
Molecular Formula:C₂₁H₂₁NO₃
Molecular Weight:335.403
Hs Code.:

Synonyms:(E)-4-(3,3-dimethyl-but-1-E-en-1-yl)-3,5-bis(4-hydroxyphenyl )isoxazole

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Chemical Property of (E)-4-(3,3-dimethyl-but-1-E-en-1-yl)-3,5-bis(4-hydroxyphenyl )isoxazole

Chemical Property:

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Technology Process of (E)-4-(3,3-dimethyl-but-1-E-en-1-yl)-3,5-bis(4-hydroxyphenyl )isoxazole

There total 4 articles about (E)-4-(3,3-dimethyl-but-1-E-en-1-yl)-3,5-bis(4-hydroxyphenyl )isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1400414-06-3
(E)-4-(3,3-dimethyl-but-1-en-1-yl)-3,5-bis(4-methoxyphenyl )isoxazole

: 1400414-32-5
(E)-4-(3,3-dimethyl-but-1-E-en-1-yl)-3,5-bis(4-hydroxyphenyl )isoxazole

Guidance literature:: With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 49h;
DOI:10.1016/j.bmcl.2012.06.097

Reference yield:

: 18362-51-1
1,3-bis(4'-methoxyphenyl)propane-1,3-dione

: 1400414-32-5
(E)-4-(3,3-dimethyl-but-1-E-en-1-yl)-3,5-bis(4-hydroxyphenyl )isoxazole

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; iodine / ethanol / 24 h / Reflux

2: N-iodo-succinimide / N,N-dimethyl-formamide / 72 h / 90 °C

3: bis-triphenylphosphine-palladium(II) chloride; water; sodium hydrogencarbonate / 1,2-dimethoxyethane / 19.5 h / 80 °C / Inert atmosphere

4: boron tribromide / dichloromethane / 49 h / -78 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; hydroxylamine hydrochloride; water; iodine; boron tribromide; sodium hydrogencarbonate; In 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide; 3: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2012.06.097

Reference yield:

: 52751-67-4
3,5-bis-(4-methoxyphenyl) isoxazole

: 1400414-32-5
(E)-4-(3,3-dimethyl-but-1-E-en-1-yl)-3,5-bis(4-hydroxyphenyl )isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodo-succinimide / N,N-dimethyl-formamide / 72 h / 90 °C

2: bis-triphenylphosphine-palladium(II) chloride; water; sodium hydrogencarbonate / 1,2-dimethoxyethane / 19.5 h / 80 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 49 h / -78 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; water; boron tribromide; sodium hydrogencarbonate; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; 2: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2012.06.097