Amprolium

Base Information

• Chemical Name: Amprolium
• CAS No.: 137-88-2
• Deprecated CAS: 8027-83-6
• Molecular Formula: C14H19ClN4^.HCl
• Molecular Weight: 315.246
• Hs Code.: 29335995
• European Community (EC) Number: 221-272-9,205-307-5,204-458-4
• NSC Number: 755872,523454
• UNII: 95CO6N199Q
• DSSTox Substance ID: DTXSID0045547
• Wikipedia: Amprolium
• Wikidata: Q27888479
• NCI Thesaurus Code: C76388
• ChEMBL ID: CHEMBL1318296
• Mol file: 137-88-2.mol

Synonyms:Amprol;Amprolium;Amprolium Chloride;Amprolium Hydrochloride;Anticoccid;Chloride, Amprolium;Hydrochloride, Amprolium;Hydrochloride, Noé-Socopharm;Némaprol;Noé Socopharm Hydrochloride;Noé-Socopharm Hydrochloride;Pyridinium, 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-methyl-, Chloride (1:1)

Chemical Property of Amprolium

Chemical Property:

• Appearance/Colour: white or white-like crystalline powder
• Melting Point: 239.0 to 243.0 °C
• PSA: 55.68000
• LogP: 0.04270
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Methanol (Slightly), Water (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 314.1065020
• Heavy Atom Count: 20
• Complexity: 246

Purity/Quality:

98%, ^*data from raw suppliers

1-(4-Amino-2-n-propyl-5-pyrimidinylmethyl)-2-methylpyridiniumChlorideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-24/25-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Uses -> Animal Feed Additives
• Canonical SMILES: CCCC1=NC=C(C(=N1)N)C[N+]2=CC=CC=C2C.Cl.[Cl-]
• Description: Amprolium is a thiamine analog and antiprotozoal agent that interferes with thiamine metabolism and inhibits carbohydrate synthesis. It competitively inhibits thiamine uptake by E. tenella schizonts and by chick host intestinal cells (Kis = 7.6 and 326 μM, respectively). It also inhibits hexose formation and pentose utilization ex vivo in isolated lysed rat erythrocytes and in liver, kidney, heart, and intestinal tissue homogenates following dietary administration. Amprolium (1,000 ppm in feed) inhibits oocyst output and sporulation of Eimeria maxima, E. brunetti, and E. acervulina in infected chicks. It also decreases lesion and oocyst scores and mortality of E. tenella-infected chicks following dietary administration of a 125 ppm dose. Amprolium (100 μM) induces apoptosis in PC12 rat adrenal cells and increases the level of cleaved caspase-3. Formulations containing amprolium have been used as coccidiostats in poultry processing.
• Uses: Coccidiostatic;Thiamine transport inhibitor 1-(4-Amino-2-n-propyl-5-pyrimidinylmethyl)-2-methylpyridinium Chloride is an antiparasytic drug used in the veterinary industry. In addition the compound shows anticoccidial activity. Thiamine analog coccidiostat.

Technology Process of Amprolium

There total 1 articles about Amprolium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 1-<(4-amino-2-n-propyl-5-pyrimidinyl)methyl>-2-picolinium chloride hydrochloride (137-88-2,3053-18-7)

Guidance literature:

4-Amino-2-propyl-pyrimidin-5-ylmethyl-chlorid-hydrochlorid, 2-Methyl-pyridin;