Technology Process of 3-[4-(benzyloxy)phenyl]-N-hydroxy-4,5-dihydroisoxazole-5-carboxamide
There total 4 articles about 3-[4-(benzyloxy)phenyl]-N-hydroxy-4,5-dihydroisoxazole-5-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydroxylamine hydrochloride; potassium hydroxide;
In
methanol;
at 0 ℃;
for 24h;
Reflux;
DOI:10.1021/jm400902y
- Guidance literature:
-
Multi-step reaction with 6 steps
1: Jones reagent / acetone / 0.08 h / 0 °C
2: sodium acetate; hydroxylamine hydrochloride / water; ethanol / 2 h / 20 °C
3: manganese(III) acetylacetonate; oxygen / methanol / 3 h / 20 °C / Green chemistry
4: sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium chlorite / acetonitrile; aq. phosphate buffer / 24 h / 35 °C / pH 7
5: methanol; benzene; hexane / 1 h / 20 °C
6: potassium hydroxide; hydroxylamine hydrochloride / methanol / 24 h / Reflux; Inert atmosphere
With
sodium hypochlorite; sodium chlorite; Jones reagent; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; hydroxylamine hydrochloride; oxygen; sodium acetate; manganese(III) acetylacetonate; potassium hydroxide;
In
methanol; aq. phosphate buffer; ethanol; hexane; water; acetone; acetonitrile; benzene;
DOI:10.1002/ejoc.201600998
- Guidance literature:
-
Multi-step reaction with 2 steps
1: triethylamine / 24 h
2: hydroxylamine hydrochloride; potassium hydroxide / methanol / 24 h / 0 °C / Reflux
With
hydroxylamine hydrochloride; triethylamine; potassium hydroxide;
In
methanol;
DOI:10.1021/jm400902y
