4-Benzyloxy-benzaldehyde oxime

Base Information

• Chemical Name: 4-Benzyloxy-benzaldehyde oxime
• CAS No.: 76193-67-4
• Molecular Formula: C14H13 N O2
• Molecular Weight: 227.263
• Hs Code.: 2928000090
• European Community (EC) Number: 809-565-5
• DSSTox Substance ID: DTXSID70416250
• Mol file: 76193-67-4.mol

Synonyms:4-Benzyloxy-benzaldehyde oxime;76193-67-4;4-(benzyloxy)benzaldehyde oxime;(NE)-N-[(4-phenylmethoxyphenyl)methylidene]hydroxylamine;N-{[4-(benzyloxy)phenyl]methylidene}hydroxylamine;4-benzyloxybenzaldehyde oxime;MFCD00195617;4-(Benzyloxy)benzaldehydeoxime;(E)-1-[4-(benzyloxy)phenyl]-N-hydroxymethanimine;SCHEMBL189964;DTXSID70416250;SLNVTNZIMUJWQW-GDNBJRDFSA-N;HMS1580O18;(Z)-4-(benzyloxy)benzaldehyde oxime;STK069353;AKOS000122324;NCGC00323558-01;CS-0220219;EN300-06089;AB01319029-02;4R-0248;A915114;AN-329/40405131;SR-01000512447;J-514506;SR-01000512447-1;Z49568539

Chemical Property of 4-Benzyloxy-benzaldehyde oxime

Chemical Property:

• Vapor Pressure: 3.55E-06mmHg at 25°C
• Refractive Index: 1.555
• Boiling Point: 371.5°C at 760 mmHg
• Flash Point: 178.5°C
• PSA: 41.82000
• Density: 1.08g/cm³
• LogP: 3.07370
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 227.094628657
• Heavy Atom Count: 17
• Complexity: 228

Purity/Quality:

98%Min ^*data from raw suppliers

4-BENZYLOXY-BENZALDEHYDE OXIME ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=C(C=C2)C=NO
• Isomeric SMILES: C1=CC=C(C=C1)COC2=CC=C(C=C2)/C=N/O

Technology Process of 4-Benzyloxy-benzaldehyde oxime

There total 8 articles about 4-Benzyloxy-benzaldehyde oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

p-benzyloxybenzaldehyde (4397-53-9) → 4-benzyloxybenzaldehyde oxime (76193-67-4)

Guidance literature:

With hydroxylamine hydrochloride;

DOI:10.1039/b305268k

Reference yield: 65.0%

benzyl bromide (100-39-0) + 4-hydroxybenzaldehyde oxime (699-06-9,60221-52-5,60221-53-6) → 4-benzyloxybenzaldehyde oxime (76193-67-4)

Guidance literature:

With potassium carbonate; tetrabutylammomium bromide; In tetrahydrofuran; at 20 ℃; for 6.66667h; 3;

DOI:10.1016/j.tetlet.2007.11.129

Reference yield:

benzyl chloride (100-44-7) → 4-benzyloxybenzaldehyde oxime (76193-67-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / potassium carbonate / acetone / 20 h / Heating

2: 75 percent / hydoxyloamine sulfate; sodium hydroxide / methanol; H₂O

With sodium hydroxide; hydroxyammonium sulfate; potassium carbonate; In methanol; water; acetone;

upstream raw materials:

p-benzyloxybenzaldehyde

benzyl chloride

4-hydroxy-benzaldehyde

benzyl bromide

Downstream raw materials:

4-(benzyloxy)benzamide

1-(4-benzyloxyphenyl)-4-(nitromethyl)benzene

N-(4-benzyloxybenzyl)acetohydroxamic acid

N-Acetoxy-N-(4-benzyloxy-benzyl)-acetamide

Refernces

• 1、 Umm-E-Farwa,Ullah, Saeed,Khan, Maria Aqeel,Zafar, Humaira,Atia-tul-Wahab,Younus, Munisaa,Choudhary, M. Iqbal,Basha, Fatima Z.. "Dibenzazepine-linked isoxazoles: New and potent class of α-glucosidase inhibitors". supporting information. . Retrieved 2021/05/10.
• 2、 Fang, Wan-Yin,Qin, Hua-Li. "Cascade Process for Direct Transformation of Aldehydes (RCHO) to Nitriles (RCN) Using Inorganic Reagents NH2OH/Na2CO3/SO2F2 in DMSO". supporting information. p. 5803 - 5812. Retrieved 2019/05/14.