Pirarubicin

Base Information

Chemical Name:Pirarubicin
CAS No.:72496-41-4
Deprecated CAS:70259-49-3
Molecular Formula:C₃₂H₃₇NO₁₂
Molecular Weight:627.645
Hs Code.:
UNII:D58G680W0G
ChEMBL ID:CHEMBL2354444
DSSTox Substance ID:DTXSID2046755
Metabolomics Workbench ID:144354
NCI Thesaurus Code:C1197
Nikkaji Number:J523.621E
Wikidata:Q76416926
Wikipedia:Pirarubicin
Mol file:72496-41-4.mol

Synonyms:4'-O-tetrahydropyranyladriamycin;4'-O-tetrahydropyranyldoxorubicin;4'-O-tetrapyranyldoxorubicin;pirarubicin;pirarubicin hydrochloride;Théprubicine;thepirubicin;Theprubicin;therarubicin;THP-ADM;THP-adriamycin;THP-DOX;THP-doxorubicin

Suppliers and Price of Pirarubicin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Pirarubicin
1mg
$ 309.00

TRC
Pirarubicin
25mg
$ 225.00

Sigma-Aldrich
Pirarubicin ≥95% (HPLC)
25mg
$ 661.00

Sigma-Aldrich
Pirarubicin ≥95% (HPLC)
10mg
$ 331.00

Medical Isotopes, Inc.
Pirarubicin
12.5 mg
$ 2400.00

DC Chemicals
Pirarubicin(THP) >98%
100 mg
$ 950.00

Crysdot
Pirarubicin 98+%
50mg
$ 169.00

Crysdot
Pirarubicin 98+%
10mg
$ 55.00

Crysdot
Pirarubicin 98+%
100mg
$ 260.00

ChemScene
Pirarubicin 99.61%
50mg
$ 240.00

Total 98 raw suppliers

Chemical Property of Pirarubicin

Chemical Property:

Appearance/Colour:Red crystalline powder
Vapor Pressure:1.51E-29mmHg at 25°C
Melting Point:188-192 °C (dec.)
Refractive Index:1.67
Boiling Point:834.659 °C at 760 mmHg
PKA:7.35±0.60(Predicted)
Flash Point:458.586 °C
PSA：204.30000
Density:1.519 g/cm³
LogP:2.25250
Storage Temp.:2-8°C
Solubility.:ethanol: soluble25mg/mL
XLogP3:2.7
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:7
Exact Mass:627.23157562
Heavy Atom Count:45
Complexity:1120

Purity/Quality:

99% ^*data from raw suppliers

Pirarubicin ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)OC6CCCCO6
Isomeric SMILES:C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O[C@@H]6CCCCO6
Recent ClinicalTrials:Adjuvant Albumin-bound Paclitaxel Versus Taxanes in Breast Cancer: a Real-world Study
Recent NIPH Clinical Trials:JCOG1403: Phase III trial of a single early intravesical instillation of pirarubicin in the prevention of bladder recurrence after nephroureterectomy for upper tract urothelial carcinoma
Description Pirarubicin is a new anthracycline anticancer agent structurally related to doxorubicin. In acute leukemia, non-Hodgkin’s lymphoma, breast and ovariail carcinoma, pirarubicin is reportedly superior to doxorubicin and better tolerated. Its major side-effect appears to be myelosuppression, mainly in the form of leucopenia, which is potentially dose-limiting.
Uses Structural analog of Doxorubicin. Antineoplastic. Structural analog of Doxorubicin. Antineoplastic

Technology Process of Pirarubicin

There total 2 articles about Pirarubicin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: