2,2,2-trifluoro-1-{[(2,4,6-trimethylbenzenesulfonyl)amino]methyl}ethyl 2,4,6-trimethylbenzenesulfonate

Base Information

• Chemical Name: 2,2,2-trifluoro-1-{[(2,4,6-trimethylbenzenesulfonyl)amino]methyl}ethyl 2,4,6-trimethylbenzenesulfonate
• CAS No.: 934986-94-4
• Molecular Formula: C₂₁H₂₆F₃NO₅S₂
• Molecular Weight: 493.568
• Mol file: 934986-94-4.mol

Synonyms:2,2,2-trifluoro-1-{[(2,4,6-trimethylbenzenesulfonyl)amino]methyl}ethyl 2,4,6-trimethylbenzenesulfonate

Chemical Property of 2,2,2-trifluoro-1-{[(2,4,6-trimethylbenzenesulfonyl)amino]methyl}ethyl 2,4,6-trimethylbenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-trifluoro-1-{[(2,4,6-trimethylbenzenesulfonyl)amino]methyl}ethyl 2,4,6-trimethylbenzenesulfonate

There total 1 articles about 2,2,2-trifluoro-1-{[(2,4,6-trimethylbenzenesulfonyl)amino]methyl}ethyl 2,4,6-trimethylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-mesitylenesulphonyl chloride (773-64-8) + 3-amino-1,1,1-trifluoropropan-2-ol (431-38-9) → 2,2,2-trifluoro-1-{[(2,4,6-trimethylbenzenesulfonyl)amino]methyl}ethyl 2,4,6-trimethylbenzenesulfonate (934986-94-4)

Guidance literature:

In pyridine; for 18h; Heating / reflux;

Reference yield: 61.0%

2,2,2-trifluoro-1-{[(2,4,6-trimethylbenzenesulfonyl)amino]methyl}ethyl 2,4,6-trimethylbenzenesulfonate (934986-94-4) → 1-(2,4,6-trimethylbenzenesulfonyl)-2-(trifluoromethyl)aziridine (897380-82-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 40 ℃; for 5.25h; Heating / reflux;

Reference yield:

2,2,2-trifluoro-1-{[(2,4,6-trimethylbenzenesulfonyl)amino]methyl}ethyl 2,4,6-trimethylbenzenesulfonate (934986-94-4) → 2,4,6-trimethyl-N-[2,2,2-trifluoro-1-({[1-(4-fluorophenyl)-1H-indazol-4-yl]oxy}methyl)ethyl]benzenesulfonamide

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 5.25 h / 40 °C / Heating / reflux

2: caesium carbonate / N,N-dimethyl-formamide / 1.33 h

With sodium hydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

2-mesitylenesulphonyl chloride

3-amino-1,1,1-trifluoropropan-2-ol

Downstream raw materials:

1-(2,4,6-trimethylbenzenesulfonyl)-2-(trifluoromethyl)aziridine