1-(2,4,6-trimethylbenzenesulfonyl)-2-(trifluoromethyl)aziridine

Base Information

• Chemical Name: 1-(2,4,6-trimethylbenzenesulfonyl)-2-(trifluoromethyl)aziridine
• CAS No.: 897380-82-4
• Molecular Formula: C₁₂H₁₄F₃NO₂S
• Molecular Weight: 293.31
• Mol file: 897380-82-4.mol

Synonyms:1-(2,4,6-trimethylbenzenesulfonyl)-2-(trifluoromethyl)aziridine

Chemical Property of 1-(2,4,6-trimethylbenzenesulfonyl)-2-(trifluoromethyl)aziridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,4,6-trimethylbenzenesulfonyl)-2-(trifluoromethyl)aziridine

There total 4 articles about 1-(2,4,6-trimethylbenzenesulfonyl)-2-(trifluoromethyl)aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,4,6-trimethyl-N-(2,2,2-trifluoro-1-hydroxymethylethyl)benzenesulfonamide (897380-81-3) → 1-(2,4,6-trimethylbenzenesulfonyl)-2-(trifluoromethyl)aziridine (897380-82-4)

Guidance literature:

With sodium hydride; p-toluenesulfonyl chloride; In tetrahydrofuran; at 20 ℃;

Reference yield: 61.0%

2,2,2-trifluoro-1-{[(2,4,6-trimethylbenzenesulfonyl)amino]methyl}ethyl 2,4,6-trimethylbenzenesulfonate (934986-94-4) → 1-(2,4,6-trimethylbenzenesulfonyl)-2-(trifluoromethyl)aziridine (897380-82-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 40 ℃; for 5.25h; Heating / reflux;

Reference yield:

2-mesitylenesulphonyl chloride (773-64-8) → 1-(2,4,6-trimethylbenzenesulfonyl)-2-(trifluoromethyl)aziridine (897380-82-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 18 h / Reflux

2: sodium hydride / tetrahydrofuran / 5 h / 40 °C / Reflux

With pyridine; sodium hydride; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2014.03.070

upstream raw materials:

2,2,2-trifluoro-1-{[(2,4,6-trimethylbenzenesulfonyl)amino]methyl}ethyl 2,4,6-trimethylbenzenesulfonate

2,4,6-trimethyl-N-(2,2,2-trifluoro-1-hydroxymethylethyl)benzenesulfonamide

2-mesitylenesulphonyl chloride

3,3,3-trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propionic acid ethyl ester

Downstream raw materials:

2,4,6-trimethyl-N-(2,2,2-trifluoro-1-phenoxymethylethyl)-benzenesulfonamide

2,4,6-trimethyl-N-[2,2,2-trifluoro-1-(quinolin-5-ylaminomethyl)ethyl]benzenesulfonamide

2,4,6-trimethyl-N-[2,2,2-trifluoro-1-(quinolin-4-yloxymethyl)ethyl]benzenesulfonamide

2,4,6-trimethyl-N-(2,2,2-trifluoro-1-phenylsulfanylmethylethyl)benzene-sulfonamide