Technology Process of N-(4-piperidin-4-yl-3-trifluoromethyl-benzoyl)-N'-(carbobenzyloxy)-guanidine
There total 12 articles about N-(4-piperidin-4-yl-3-trifluoromethyl-benzoyl)-N'-(carbobenzyloxy)-guanidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane;
at 50 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -75 °C
1.2: -75 - 0 °C
1.3: 0.17 h / Cooling
2.1: potassium acetate / (diphenylphosphin)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C
3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 4 h / 140 °C / Sealed tube
4.1: water; potassium carbonate / methanol / 2 h / 60 °C
4.2: pH ~ 4
5.1: hydrogen / palladium 10% on activated carbon / methanol / 3102.97 Torr
6.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 1.5 h
7.1: hydrogenchloride / 1,4-dioxane / 16 h / 50 °C
With
hydrogenchloride; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; potassium acetate; potassium carbonate; lithium hexamethyldisilazane;
(diphenylphosphin)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; water;
3.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium acetate / (diphenylphosphin)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C
2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 4 h / 140 °C / Sealed tube
3.1: water; potassium carbonate / methanol / 2 h / 60 °C
3.2: pH ~ 4
4.1: hydrogen / palladium 10% on activated carbon / methanol / 3102.97 Torr
5.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 1.5 h
6.1: hydrogenchloride / 1,4-dioxane / 16 h / 50 °C
With
hydrogenchloride; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; potassium acetate; potassium carbonate;
(diphenylphosphin)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; water;
2.1: Suzuki Coupling;