N-{4-[1-(6-hydroxy-pyridine-3-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-guanidine

Base Information

Chemical Name:N-{4-[1-(6-hydroxy-pyridine-3-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-guanidine
CAS No.:1204329-36-1
Molecular Formula:C₂₀H₂₀F₃N₅O₃
Molecular Weight:435.406
Hs Code.:

Synonyms:N-{4-[1-(6-hydroxy-pyridine-3-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-guanidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{4-[1-(6-hydroxy-pyridine-3-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-guanidine

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Technology Process of N-{4-[1-(6-hydroxy-pyridine-3-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-guanidine

There total 19 articles about N-{4-[1-(6-hydroxy-pyridine-3-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1204331-68-9
1-(N-carbobenzyloxy)-3-{4-[1-(6-benzyloxy-pyridine-3-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-guanidine

: 1204329-36-1
N-{4-[1-(6-hydroxy-pyridine-3-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-guanidine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 24h;

Reference yield:

: 161622-14-6
4-bromo-3-(trifluoromethyl)benzoic acid

: 1204329-36-1
N-{4-[1-(6-hydroxy-pyridine-3-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-guanidine

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / 80 °C

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 140 °C

3.1: hydrogen; acetic acid; platinum(IV) oxide / 60 h / Inert atmosphere

4.1: potassium carbonate; hydrogenchloride / methanol; water / 16 h / 20 °C

5.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 1 h / 20 - 50 °C

5.2: 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 16 h

7.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide

7.2: 20 °C

8.1: hydrogen; 10% Pd/C / methanol / 48 h / 760.05 Torr

With hydrogenchloride; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; 10% Pd/C; 2-chloro-1-methyl-pyridinium iodide; hydrogen; potassium carbonate; acetic acid; 1,1'-carbonyldiimidazole; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; water; N,N-dimethyl-formamide; 2.1: |Suzuki Coupling;
DOI:10.1021/jm300601d

Reference yield:

: 1204331-26-9
4-(4-methoxycarbonyl-2-trifluoromethylphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1204329-36-1
N-{4-[1-(6-hydroxy-pyridine-3-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-guanidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen; acetic acid; platinum(IV) oxide / 60 h / Inert atmosphere

2.1: potassium carbonate; hydrogenchloride / methanol; water / 16 h / 20 °C

3.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 1 h / 20 - 50 °C

3.2: 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 16 h

5.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide

5.2: 20 °C

6.1: hydrogen; 10% Pd/C / methanol / 48 h / 760.05 Torr

With hydrogenchloride; platinum(IV) oxide; 10% Pd/C; 2-chloro-1-methyl-pyridinium iodide; hydrogen; potassium carbonate; acetic acid; 1,1'-carbonyldiimidazole; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm300601d