Technology Process of 4-(1-isopropylpiperidin-4-yl)phenylamine
There total 9 articles about 4-(1-isopropylpiperidin-4-yl)phenylamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium on activated charcoal; hydrogen;
In
methanol;
at 20 ℃;
for 16h;
under 2068.65 Torr;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate / acetonitrile / 0.75 h / 120 °C
2: hydrazine / palladium 10% on activated carbon / ethanol; water / 3 h / Heating / reflux
With
potassium carbonate; hydrazine;
palladium 10% on activated carbon;
In
ethanol; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: lithium hexamethyldisilazane / tetrahydrofuran / 19 h / -78 - 20 °C / Inert atmosphere
2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; 1,4-dioxane / 16 h / 80 - 90 °C / Inert atmosphere
3: sodium hydroxide / water; toluene / 16 h / 0 - 20 °C
4: trifluoroacetic acid / dichloromethane / 3 h / 20 °C
5: potassium carbonate / acetonitrile / 16 h / 50 °C
6: palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C / 2068.65 Torr
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; hydrogen; potassium carbonate; trifluoroacetic acid; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; toluene; acetonitrile;
