Tert-butyl 4-(4-aminophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Base Information

Chemical Name:Tert-butyl 4-(4-aminophenyl)-5,6-dihydropyridine-1(2H)-carboxylate
CAS No.:873454-43-4
Molecular Formula:C₁₆H₂₂N₂O₂
Molecular Weight:274.363
Hs Code.:
DSSTox Substance ID:DTXSID40697034
Wikidata:Q82626845

Synonyms:873454-43-4;TERT-BUTYL 4-(4-AMINOPHENYL)-5,6-DIHYDROPYRIDINE-1(2H)-CARBOXYLATE;tert-butyl 4-(4-aminophenyl)-3,6-dihydro-2H-pyridine-1-carboxylate;4-(4-aminophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester;tert-butyl 4-(4-aminophenyl)-1,2,3,6-tetrahydropyridine-1-carboxylate;SCHEMBL2908091;DTXSID40697034;CNCSOOBVWRVUSB-UHFFFAOYSA-N;AKOS040804399;FT-0727664;EN300-1171470;A842103;Z1508686799;tert-Butyl 4-(4-aminophenyl)-3,6-dihydropyridine-1(2H)-carboxylate;4-(4-Amino-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Suppliers and Price of Tert-butyl 4-(4-aminophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of Tert-butyl 4-(4-aminophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:274.168127949
Heavy Atom Count:20
Complexity:376

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(=CC1)C2=CC=C(C=C2)N

Technology Process of Tert-butyl 4-(4-aminophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

There total 8 articles about Tert-butyl 4-(4-aminophenyl)-5,6-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 387827-33-0
tert-butyl 4-(4-nitrophenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 873454-43-4
4-(4-aminophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:: With tin(ll) chloride; In ethanol; at 55 ℃; for 3h;

Reference yield: 63.0%

: 138647-49-1
4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 214360-73-3
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline

: 873454-43-4
4-(4-aminophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium chloride; In 1,4-dioxane; ethanol; water; toluene; at 80 ℃; Inert atmosphere;
DOI:10.1021/jm200900q

Reference yield:

: 106-40-1
4-bromo-aniline

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 873454-43-4
4-(4-aminophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:: 4-bromo-aniline; tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate; With sodium carbonate; In water; N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 90 ℃; for 3h;