ethyl 4,6-dichloro-3-((3-(3-chloro-4-(2-fluoroethoxy)phenyl)-1-(2-methoxy-oxoethyl)ureido)methyl)-indole-2-carboxylate

Base Information

Chemical Name:ethyl 4,6-dichloro-3-((3-(3-chloro-4-(2-fluoroethoxy)phenyl)-1-(2-methoxy-oxoethyl)ureido)methyl)-indole-2-carboxylate
CAS No.:1335465-66-1
Molecular Formula:C₂₄H₂₃Cl₃FN₃O₆
Molecular Weight:574.821
Hs Code.:

Synonyms:ethyl 4,6-dichloro-3-((3-(3-chloro-4-(2-fluoroethoxy)phenyl)-1-(2-methoxy-oxoethyl)ureido)methyl)-indole-2-carboxylate

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Chemical Property of ethyl 4,6-dichloro-3-((3-(3-chloro-4-(2-fluoroethoxy)phenyl)-1-(2-methoxy-oxoethyl)ureido)methyl)-indole-2-carboxylate

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Technology Process of ethyl 4,6-dichloro-3-((3-(3-chloro-4-(2-fluoroethoxy)phenyl)-1-(2-methoxy-oxoethyl)ureido)methyl)-indole-2-carboxylate

There total 8 articles about ethyl 4,6-dichloro-3-((3-(3-chloro-4-(2-fluoroethoxy)phenyl)-1-(2-methoxy-oxoethyl)ureido)methyl)-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65617-96-1
3-chloro-4-(2-fluoroethoxy)aniline

: 1335465-66-1
ethyl 4,6-dichloro-3-((3-(3-chloro-4-(2-fluoroethoxy)phenyl)-1-(2-methoxy-oxoethyl)ureido)methyl)-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

2: dichloromethane / 0 - 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1002/jlcr.1901

Reference yield:

: 619-08-9
2-chloro-4-nitrophenol

: 1335465-66-1
ethyl 4,6-dichloro-3-((3-(3-chloro-4-(2-fluoroethoxy)phenyl)-1-(2-methoxy-oxoethyl)ureido)methyl)-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 48 h / Reflux

2: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 0 °C / 750.08 Torr

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

4: dichloromethane / 0 - 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; acetone;
DOI:10.1002/jlcr.1901

Reference yield:

: 4,6-dichloro-3-(methoxycarbonylmethylimino-methyl)-1H-indole-2-carboxylic acid ethyl ester

: 1335465-66-1
ethyl 4,6-dichloro-3-((3-(3-chloro-4-(2-fluoroethoxy)phenyl)-1-(2-methoxy-oxoethyl)ureido)methyl)-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 1.5 h / Inert atmosphere

2: dichloromethane / 0 - 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; In dichloromethane;
DOI:10.1002/jlcr.1901