ethyl 4,6-dichloro-1H-indole-2-carboxylate

Base Information

• Chemical Name: ethyl 4,6-dichloro-1H-indole-2-carboxylate
• CAS No.: 53995-82-7
• Molecular Formula: C11H9Cl2NO2
• Molecular Weight: 258.104
• Hs Code.: 2933998090
• European Community (EC) Number: 675-926-7
• DSSTox Substance ID: DTXSID10371339
• Wikidata: Q72474226
• Mol file: 53995-82-7.mol

Synonyms:ethyl 4,6-dichloro-1H-indole-2-carboxylate;53995-82-7;ethyl 4,6-dichloroindole-2-carboxylate;1H-Indole-2-carboxylic acid, 4,6-dichloro-, ethyl ester;4,6-dichloroindole-2-carboxylic acid ethyl ester;ETHYL4,6-DICHLORO-1H-INDOLE-2-CARBOXYLATE;4,6-dichloro-1h-indole-2-carboxylic acid ethyl ester;SCHEMBL1093057;AMY1755;DTXSID10371339;2-carboethoxy-4,6-dichloroindole;YLAHLUPONQVSOT-UHFFFAOYSA-N;BBL020614;MFCD00800654;STK893304;AKOS001476262;AB07295;AC-9001;ETHYL 4,6-DICHLORO-1H-INDOLE;ethyl,4,6-dichloroindole-2-carboxylate;NCGC00336984-01;DS-10621;A7846;CS-0139911;Ethyl?4,6-dichloro-1H-indole-2-carboxylate;FT-0649146;EN300-85655;AB01330205-02;4,6-dichloro-indole-2-carboxylic acid, ethyl ester;Q-102090;Z425372998;4,6-dichloro-1-ethyl-1H-indole;ETHYL 4,6-DICHLORO-1H-INDOLE-2-CARBOXYLATE

Chemical Property of ethyl 4,6-dichloro-1H-indole-2-carboxylate

Chemical Property:

• Vapor Pressure: 9.06E-07mmHg at 25°C
• Melting Point: 171-172 °C
• Refractive Index: 1.637
• Boiling Point: 405 °C at 760 mmHg
• PKA: 13.21±0.30(Predicted)
• Flash Point: 198.7 °C
• Density: 1.432 g/cm³
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 257.0010339
• Heavy Atom Count: 16
• Complexity: 275

Purity/Quality:

98% ^*data from raw suppliers

Ethyl4,6-dichloro-1h-indole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CC2=C(N1)C=C(C=C2Cl)Cl

Technology Process of ethyl 4,6-dichloro-1H-indole-2-carboxylate

There total 9 articles about ethyl 4,6-dichloro-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 2-[2-(3,5-dichlorophenyl)hydrazinylidene]propanoate (103855-01-2) → 4,6-dichloro-indole-2-carboxylic acid,ethyl ester (53995-82-7)

Guidance literature:

With polyphosphoric acid; In toluene; at 20 ℃; Heating / reflux;

Reference yield: 96.5%

(E)-ethyl 2-(2-(3,5-dichlorophenyl)hydrazono)propanoate (137836-38-5) → 4,6-dichloro-indole-2-carboxylic acid,ethyl ester (53995-82-7)

Guidance literature:

With polyphosphoric acid; In toluene; at 45 ℃;

DOI:10.1021/acsmedchemlett.5b00482

Reference yield:

2-oxo-propionic acid ethyl ester (617-35-6) + (3,5-dichlorophenyl)hydrazine hydrochloride (63352-99-8) → 4,6-dichloro-indole-2-carboxylic acid,ethyl ester (53995-82-7)

Guidance literature:

With toluene-4-sulfonic acid; In water; benzene; at 140 ℃; Dean-Stark; Inert atmosphere;

upstream raw materials:

(E)-ethyl 2-(2-(3,5-dichlorophenyl)hydrazono)propanoate

ethyl 2-[2-(3,5-dichlorophenyl)hydrazinylidene]propanoate

(3,5-dichlorophenyl)hydrazine hydrochloride

3,5-Dichloroaniline

Downstream raw materials:

4,6-dichloro-1H-indole-2-carboxylic acid

ethyl-3-formyl-4,6-dichloro-indole-2-carboxylate

ethyl (Z)-4,6-dichloro-3-[2-(3-aminophenyl)2-cyanoethenyl]-1H-indole-2-carboxylate

ethyl (Z)-4,6-dichloro-3-[(3-amino-2-aminophenyl)-3-oxo-1-propenyl]-1H-indole-2-carboxylate