(3aS,6aR,7S,8S,11S,11aR,11bS)-8-Allyl-7,11-bis-benzyloxy-8-(ethyl-dimethyl-silanyloxy)-2,2,9,9,11b-pentamethyl-6-methylene-decahydro-1,3-dioxa-cycloocta[de]naphthalen-10-one

Base Information

Chemical Name:(3aS,6aR,7S,8S,11S,11aR,11bS)-8-Allyl-7,11-bis-benzyloxy-8-(ethyl-dimethyl-silanyloxy)-2,2,9,9,11b-pentamethyl-6-methylene-decahydro-1,3-dioxa-cycloocta[de]naphthalen-10-one
CAS No.:248252-89-3
Molecular Formula:C₄₀H₅₆O₆Si
Molecular Weight:660.967
Hs Code.:

(3aS,6aR,7S,8S,11S,11aR,11bS)-8-Allyl-7,11-bis-benzyloxy-8-(ethyl-dimethyl-silanyloxy)-2,2,9,9,11b-pentamethyl-6-methylene-decahydro-1,3-dioxa-cycloocta[de]naphthalen-10-one

Synonyms:(3aS,6aR,7S,8S,11S,11aR,11bS)-8-Allyl-7,11-bis-benzyloxy-8-(ethyl-dimethyl-silanyloxy)-2,2,9,9,11b-pentamethyl-6-methylene-decahydro-1,3-dioxa-cycloocta[de]naphthalen-10-one

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Chemical Property of (3aS,6aR,7S,8S,11S,11aR,11bS)-8-Allyl-7,11-bis-benzyloxy-8-(ethyl-dimethyl-silanyloxy)-2,2,9,9,11b-pentamethyl-6-methylene-decahydro-1,3-dioxa-cycloocta[de]naphthalen-10-one

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Technology Process of (3aS,6aR,7S,8S,11S,11aR,11bS)-8-Allyl-7,11-bis-benzyloxy-8-(ethyl-dimethyl-silanyloxy)-2,2,9,9,11b-pentamethyl-6-methylene-decahydro-1,3-dioxa-cycloocta[de]naphthalen-10-one

There total 9 articles about (3aS,6aR,7S,8S,11S,11aR,11bS)-8-Allyl-7,11-bis-benzyloxy-8-(ethyl-dimethyl-silanyloxy)-2,2,9,9,11b-pentamethyl-6-methylene-decahydro-1,3-dioxa-cycloocta[de]naphthalen-10-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: (3aS,6aR,7S,8S,10R,11R,11aR,11bS)-8-Allyl-7,11-bis-benzyloxy-8-(ethyl-dimethyl-silanyloxy)-2,2,9,9,11b-pentamethyl-6-methylene-dodecahydro-1,3-dioxa-cycloocta[de]naphthalen-10-ol

: 248252-89-3
(3aS,6aR,7S,8S,11S,11aR,11bS)-8-Allyl-7,11-bis-benzyloxy-8-(ethyl-dimethyl-silanyloxy)-2,2,9,9,11b-pentamethyl-6-methylene-decahydro-1,3-dioxa-cycloocta[de]naphthalen-10-one

Guidance literature:: With dipyridinium dichromate; In dichloromethane; at 20 ℃;
DOI:10.1246/cl.1999.817

Reference yield:

: 194420-17-2
2α,10β-dibenzyloxy-11β-(t-butyldimethylsiloxy)-7β-hydroxy-1α-(p-methoxybenzyloxy)-8β,15,15-trimethyl-4-methylene-trans-bicyclo[6.4.0]dodecan-9-one

: 248252-89-3
(3aS,6aR,7S,8S,11S,11aR,11bS)-8-Allyl-7,11-bis-benzyloxy-8-(ethyl-dimethyl-silanyloxy)-2,2,9,9,11b-pentamethyl-6-methylene-decahydro-1,3-dioxa-cycloocta[de]naphthalen-10-one

Guidance literature:: Multi-step reaction with 9 steps

1: 83 percent / DIBAL / CH₂Cl₂ / 0 - 20 °C

2: 100 percent / camphorsulfonic acid / CH₂Cl₂ / 20 °C

3: 92 percent / DDQ / H₂O; CH₂Cl₂ / 20 °C

4: 92 percent / PDC / CH₂Cl₂ / 20 °C

5: 100 percent / diethyl ether / -45 °C

6: 100 percent / TBAF / tetrahydrofuran / 0 °C

7: 100 percent / pyridine / 0 °C

8: 83 percent / toluene / -45 °C

9: 86 percent / PDC / CH₂Cl₂ / 20 °C

With pyridine; dipyridinium dichromate; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; diethyl ether; dichloromethane; water; toluene; 1: Reduction / 2: Etherification / 3: deprotection / 4: Oxidation / 5: allylation / 6: deprotection / 7: Etherification / 8: Methylation / 9: Oxidation;
DOI:10.1246/cl.1999.817

Reference yield:

: (3aS,6aR,7S,8S,10R,11R,11aR,11bS)-8-Allyl-7,11-bis-benzyloxy-2,2,9,9,11b-pentamethyl-6-methylene-dodecahydro-1,3-dioxa-cycloocta[de]naphthalene-8,10-diol

: 248252-89-3
(3aS,6aR,7S,8S,11S,11aR,11bS)-8-Allyl-7,11-bis-benzyloxy-8-(ethyl-dimethyl-silanyloxy)-2,2,9,9,11b-pentamethyl-6-methylene-decahydro-1,3-dioxa-cycloocta[de]naphthalen-10-one

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / pyridine / 0 °C

2: 83 percent / toluene / -45 °C

3: 86 percent / PDC / CH₂Cl₂ / 20 °C

With pyridine; dipyridinium dichromate; In dichloromethane; toluene; 1: Etherification / 2: Methylation / 3: Oxidation;
DOI:10.1246/cl.1999.817