(S)-methyl 1-(2,5-dichlorobenzyl)-4,4-difluoropyrrolidine-2-carboxylate

Base Information

Chemical Name:(S)-methyl 1-(2,5-dichlorobenzyl)-4,4-difluoropyrrolidine-2-carboxylate
CAS No.:1445984-74-6
Molecular Formula:C₁₃H₁₃Cl₂F₂NO₂
Molecular Weight:324.155
Hs Code.:

Synonyms:(S)-methyl 1-(2,5-dichlorobenzyl)-4,4-difluoropyrrolidine-2-carboxylate

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Chemical Property of (S)-methyl 1-(2,5-dichlorobenzyl)-4,4-difluoropyrrolidine-2-carboxylate

Chemical Property:

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Technology Process of (S)-methyl 1-(2,5-dichlorobenzyl)-4,4-difluoropyrrolidine-2-carboxylate

There total 4 articles about (S)-methyl 1-(2,5-dichlorobenzyl)-4,4-difluoropyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126111-14-6
methyl (2S)-4,4-difluoropyrrolidine-2-carboxylate

: 85482-13-9
2,5-dichlorobenzylbromide

: 1445984-74-6
(S)-methyl 1-(2,5-dichlorobenzyl)-4,4-difluoropyrrolidine-2-carboxylate

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃;

Reference yield:

: 102195-80-2
(S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate

: 1445984-74-6
(S)-methyl 1-(2,5-dichlorobenzyl)-4,4-difluoropyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: potassium carbonate / acetonitrile / 20 °C

With diethylamino-sulfur trifluoride; potassium carbonate; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00308

Reference yield:

: 74844-91-0
1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

: 1445984-74-6
(S)-methyl 1-(2,5-dichlorobenzyl)-4,4-difluoropyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 - -60 °C

1.2: 20 °C

2.1: diethylamino-sulfur trifluoride / dichloromethane / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: potassium carbonate / acetonitrile / 20 °C

With oxalyl dichloride; diethylamino-sulfur trifluoride; potassium carbonate; dimethyl sulfoxide; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00308