5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene

Base Information

Chemical Name:5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene
CAS No.:179894-98-5
Molecular Formula:C₂₅H₂₂ClNO
Molecular Weight:387.909
Hs Code.:

5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-1<i>H</i>-6-oxa-1-aza-chrysene

Synonyms:5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene

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Technology Process of 5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene

There total 1 articles about 5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14774-78-8
4-chlorophenyl lithium

: 179894-93-0
2,2,4-trimethyl-1,2-dihydro-6-oxa-1-azachrysen-5-one

: 179894-97-4,179895-06-8,201593-64-8
(-)-5-(4-Chlorophenyl)-1,2-dihydro-2,2,4-trimethyl-5H-chromeno[3,4-f]quinoline

: 179894-98-5
5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene

Guidance literature:: With triethylsilane; trifluoroacetic acid; Yield given; Multistep reaction; 1.) THF, -30 deg, 2.) CH₂Cl₂, RT;
DOI:10.1021/jm980723h

Reference yield: 59.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 179894-98-5
5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene

: 179898-59-0
5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-6-oxa-1-aza-chrysene-1-carboxylic acid tert-butyl ester

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1021/jm980723h

Reference yield:

: 179894-98-5
5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene

: 5-(4-chloro-phenyl)-2,2-dimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene

Guidance literature:: Multi-step reaction with 5 steps

1: 59 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C

2: 1.) O₃, 2.) SMe₂ / 1.) MeOH, -78 deg C, 3 min, 2.) MeOH, from -78 deg C to RT

3: TFA / CH₂Cl₂

4: DIBAL-H / toluene / Ambient temperature

5: TsOH / CH₂Cl₂ / 3 h / Ambient temperature

With n-butyllithium; dimethylsulfide; diisobutylaluminium hydride; toluene-4-sulfonic acid; ozone; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1021/jm980723h