2-(2,6-dichlorobenzyl)-4-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one

Base Information

Chemical Name:2-(2,6-dichlorobenzyl)-4-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one
CAS No.:1391418-80-6
Molecular Formula:C₂₅H₂₄Cl₂N₆O₂
Molecular Weight:511.411
Hs Code.:

Synonyms:2-(2,6-dichlorobenzyl)-4-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one

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Chemical Property of 2-(2,6-dichlorobenzyl)-4-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one

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Technology Process of 2-(2,6-dichlorobenzyl)-4-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one

There total 11 articles about 2-(2,6-dichlorobenzyl)-4-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(2-methoxy-4-(piperazin-1-yl)phenylamino)-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one

: 117269-75-7
(2,6-dichlorobenzyl)zinc(II) bromide

: 1391418-80-6
2-(2,6-dichlorobenzyl)-4-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one

Guidance literature:: bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 100 ℃; for 0.666667h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 448-19-1
4-fluoro-2-methoxy-1-nitrobenzene

: 1391418-80-6
2-(2,6-dichlorobenzyl)-4-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

2: hydrogen / Raney nickel / methanol / 5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 9 h / 70 °C

4: 1.5 h / 110 °C

5: hydrogen bromide; acetic acid / 1 h / 20 °C

6: hydrogenchloride; acetic acid / water / 1.5 h / 80 °C

7: bis-triphenylphosphine-palladium(II) chloride / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 0.67 h / 100 °C / Microwave irradiation; Inert atmosphere

With hydrogenchloride; hydrogen bromide; hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1246532-96-6
tert-butyl 4-(4-amino-3-methoxy-phenyl)-piperazine-1-carboxylate

: 1391418-80-6
2-(2,6-dichlorobenzyl)-4-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 9 h / 70 °C

2: 1.5 h / 110 °C

3: hydrogen bromide; acetic acid / 1 h / 20 °C

4: hydrogenchloride; acetic acid / water / 1.5 h / 80 °C

5: bis-triphenylphosphine-palladium(II) chloride / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 0.67 h / 100 °C / Microwave irradiation; Inert atmosphere

With hydrogenchloride; hydrogen bromide; acetic acid; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide;