Benzoic acid (R)-1-[(1R,2R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-formyl-1-methyl-cyclohexyl]-allyl ester

Base Information

• Chemical Name: Benzoic acid (R)-1-[(1R,2R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-formyl-1-methyl-cyclohexyl]-allyl ester
• CAS No.: 146861-60-1
• Molecular Formula: C₅₁H₆₀O₅Si₂
• Molecular Weight: 809.205
• Mol file: 146861-60-1.mol

Synonyms:Benzoic acid (R)-1-[(1R,2R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-formyl-1-methyl-cyclohexyl]-allyl ester

Chemical Property of Benzoic acid (R)-1-[(1R,2R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-formyl-1-methyl-cyclohexyl]-allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid (R)-1-[(1R,2R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-formyl-1-methyl-cyclohexyl]-allyl ester

There total 4 articles about Benzoic acid (R)-1-[(1R,2R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-formyl-1-methyl-cyclohexyl]-allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

Benzoic acid (1S,3S,4S,4aR,7R,8R,8aR)-3-bromomethyl-7-(tert-butyl-diphenyl-silanyloxy)-8-(tert-butyl-diphenyl-silanyloxymethyl)-1-methoxy-4a-methyl-octahydro-isochromen-4-yl ester → Benzoic acid (R)-1-[(1R,2R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-formyl-1-methyl-cyclohexyl]-allyl ester (146861-60-1)

Guidance literature:

With zinc; In isopropyl alcohol; for 5h; Heating;

DOI:10.1039/c39930000151

Reference yield:

(1R,2S,4R,7R,9S,10R,11R,12R)-11-hydroxymethyl-9-methoxy-1-methyl-4-phenyl-3,5,8-trioxatricyclo<8.7.0.02,7>-tetradecan-12-ol (127818-07-9) → Benzoic acid (R)-1-[(1R,2R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-formyl-1-methyl-cyclohexyl]-allyl ester (146861-60-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / imidazole / CH₂Cl₂ / 72 h / Ambient temperature

2: 80 percent / N-bromosuccinimide (NBS), BaCO₃ / CCl₄ / 3 h / Heating

3: 61 percent / Zn / propan-2-ol / 5 h / Heating

With 1H-imidazole; N-Bromosuccinimide; barium carbonate; zinc; In tetrachloromethane; dichloromethane; isopropyl alcohol;

DOI:10.1039/c39930000151

Reference yield:

(3R,4aS,4bR,7R,8R,8aR,9S,10aR)-7-(tert-Butyl-diphenyl-silanyloxy)-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methoxy-4b-methyl-3-phenyl-decahydro-2,4,10-trioxa-phenanthrene → Benzoic acid (R)-1-[(1R,2R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-formyl-1-methyl-cyclohexyl]-allyl ester (146861-60-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / N-bromosuccinimide (NBS), BaCO₃ / CCl₄ / 3 h / Heating

2: 61 percent / Zn / propan-2-ol / 5 h / Heating

With N-Bromosuccinimide; barium carbonate; zinc; In tetrachloromethane; isopropyl alcohol;

DOI:10.1039/c39930000151

upstream raw materials:

(1R,2S,4R,7R,9S,10R,11R,12R)-11-hydroxymethyl-9-methoxy-1-methyl-4-phenyl-3,5,8-trioxatricyclo<8.7.0.0^2,7>-tetradecan-12-ol

tert-butylchlorodiphenylsilane

Downstream raw materials:

Benzoic acid (S)-1-[(1R,2R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-2-triethylsilanyloxymethyl-cyclohexyl]-2-oxo-ethyl ester