1-(3-Indolylmethyl)nipecotic acid ethyl ester

Base Information

• Chemical Name: 1-(3-Indolylmethyl)nipecotic acid ethyl ester
• CAS No.: 101602-77-1
• Molecular Formula: C17H22N2O2
• Molecular Weight: 286.37
• Mol file: 101602-77-1.mol

Synonyms:1-(3-Indolylmethyl)nipecotic acid ethyl ester

Chemical Property of 1-(3-Indolylmethyl)nipecotic acid ethyl ester

Chemical Property:

• Vapor Pressure: 1.31E-07mmHg at 25°C
• Boiling Point: 430.3°Cat760mmHg
• Flash Point: 214°C
• PSA: 45.33000
• Density: 1.181g/cm³
• LogP: 2.88090

Purity/Quality:

98%min ^*data from raw suppliers

1-(3-INDOLYLMETHYL)NIPECOTIC ACID ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-Indolylmethyl)nipecotic acid ethyl ester

There total 2 articles about 1-(3-Indolylmethyl)nipecotic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-pyridinecarboxylic acid ethyl ester (614-18-6) → 1-indol-3-ylmethyl-piperidine-3-carboxylic acid ethyl ester (101602-77-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Raney nickel; dioxane / 165 °C / 110326 - 220652 Torr / Hydrogenation

2: acetic acid

With 1,4-dioxane; nickel; acetic acid;

Reference yield:

indole (120-72-9) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + Ethyl nipecotate (71962-74-8) → 1-indol-3-ylmethyl-piperidine-3-carboxylic acid ethyl ester (101602-77-1)

Guidance literature:

With acetic acid;

DOI:10.1002/jps.3030401119

upstream raw materials:

indole

formaldehyd

Ethyl nipecotate

3-pyridinecarboxylic acid ethyl ester