N-(2,4-dimethylphenyl)-4-(1-hydroxy-3-(2-trityl-2H-tetrazol-5-yl)propyl)-N-isobutylbenzenesulfonamide

Base Information

Chemical Name:N-(2,4-dimethylphenyl)-4-(1-hydroxy-3-(2-trityl-2H-tetrazol-5-yl)propyl)-N-isobutylbenzenesulfonamide
CAS No.:1429347-63-6
Molecular Formula:C₄₁H₄₃N₅O₃S
Molecular Weight:685.89
Hs Code.:

Synonyms:N-(2,4-dimethylphenyl)-4-(1-hydroxy-3-(2-trityl-2H-tetrazol-5-yl)propyl)-N-isobutylbenzenesulfonamide

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Chemical Property of N-(2,4-dimethylphenyl)-4-(1-hydroxy-3-(2-trityl-2H-tetrazol-5-yl)propyl)-N-isobutylbenzenesulfonamide

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Technology Process of N-(2,4-dimethylphenyl)-4-(1-hydroxy-3-(2-trityl-2H-tetrazol-5-yl)propyl)-N-isobutylbenzenesulfonamide

There total 4 articles about N-(2,4-dimethylphenyl)-4-(1-hydroxy-3-(2-trityl-2H-tetrazol-5-yl)propyl)-N-isobutylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429347-55-6
N-(2,4-dimethylphenyl)-N-isobutyl-4-(oxiran-2-yl)benzenesulfonamide

: 178323-88-1
5-methyl-2-trityl-2H-tetrazole

: 1429347-63-6
N-(2,4-dimethylphenyl)-4-(1-hydroxy-3-(2-trityl-2H-tetrazol-5-yl)propyl)-N-isobutylbenzenesulfonamide

Guidance literature:: 5-methyl-2-trityl-2H-tetrazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -70 ℃; for 0.766667h; Inert atmosphere;

N-(2,4-dimethylphenyl)-N-isobutyl-4-(oxiran-2-yl)benzenesulfonamide; In tetrahydrofuran; hexane; at -78 ℃; for 1.01667h; Inert atmosphere;

Reference yield:

: 1429346-28-0
4-bromo-N-(2,4-dimethylphenyl)-N-isobutylbenzenesulfonamide

: 1429347-63-6
N-(2,4-dimethylphenyl)-4-(1-hydroxy-3-(2-trityl-2H-tetrazol-5-yl)propyl)-N-isobutylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; caesium carbonate; palladium dichloride / water; tetrahydrofuran / 1.5 h / 140 °C / Microwave irradiation

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 25 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.77 h / -78 - -70 °C / Inert atmosphere

3.2: 1.02 h / -78 °C / Inert atmosphere

With n-butyllithium; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; palladium dichloride; In tetrahydrofuran; hexane; dichloromethane; water;

Reference yield:

: 76-83-5
trityl chloride

: 1429347-63-6
N-(2,4-dimethylphenyl)-4-(1-hydroxy-3-(2-trityl-2H-tetrazol-5-yl)propyl)-N-isobutylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane / 72 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.77 h / -78 - -70 °C / Inert atmosphere

2.2: 1.02 h / -78 °C / Inert atmosphere

With n-butyllithium; tetrabutylammomium bromide; sodium hydroxide; In tetrahydrofuran; hexane; dichloromethane;