178323-88-1

Basic information

• Product Name: 2H-Tetrazole, 5-methyl-2-(triphenylmethyl)-
• CAS NO: 178323-88-1
• Molecular Formula: C21H18N4
• Molecular Weight: 326.401
• Mol File: 178323-88-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2H-Tetrazole, 5-methyl-2-(triphenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Tetrazole, 5-methyl-2-(triphenylmethyl)-(178323-88-1)
• EPA Substance Registry System: 2H-Tetrazole, 5-methyl-2-(triphenylmethyl)-(178323-88-1)

Safety Data

• Hazardous Substances Data: 178323-88-1(Hazardous Substances Data)

Upstream product

• 4076-36-2 5-methyl-1,2,3,4-tetrazole 
• 76-83-5 trityl chloride 
• 76-84-6 triphenylmethyl alcohol 
• 4076-36-2 5-methyltetrazole 

Downstream Products

• 1429347-66-9 N-(2,4-dimethylphenyl)-4-(2-hydroxy-1-(2-trityl-2H-tetrazol-5-yl)propan-2-yl)-N-isobutylbenzenesulfonamide 
• 1429347-63-6 N-(2,4-dimethylphenyl)-4-(1-hydroxy-3-(2-trityl-2H-tetrazol-5-yl)propyl)-N-isobutylbenzenesulfonamide 
• 178323-84-7 5-Pentyl-2-trityl-2H-tetrazole 
• 178323-78-9 4-Phenyl-1-(2-trityl-2H-tetrazol-5-yl)-butan-2-ol 

Relevant articles and documents

Application of Photoclick Chemistry for the Synthesis of Pyrazoles via 1,3-Dipolar Cycloaddition between Alkynes and Nitrilimines Generated In Situ

The photochemical extrusion of gaseous nitrogen from 2,5-disubstituted tetrazoles to generate reactive nitrilimines in situ represents an efficient and attractive way to form dipoles that can be used to provide useful chemicals via 1,3-dipolar cycloadditions. The concept of “photoclick chemistry” already inspired numerous researchers, who exploited photochemical processes involving alkenes for the synthesis of adducts or the functionalization of biocompatible materials. The approach requires bioorthogonality, ease of access to the starting materials and operational simplicity. We report herein our investigations toward a photoclick reaction involving 2,5-disubstituted tetrazoles and alkynes as the dipolarophile for the synthesis of pyrazole derivatives. In addition to the numerous reports recently published on the synthesis of pyrazoles, we wish to add to the list a photochemical procedure that represents a mild and atom-economical alternative. Moreover, considering that such nitrilimines precursors can be accessed in one step from inexpensive and abundant starting materials and given the commercial availability of a broad spectrum of alkynes, we examined the scope of the photoclick reaction with respect to reactive partners, enabling the synthesis of a library of useful heteroaromatics.

SULFONAMIDE COMPOUNDS AND THEIR USE IN THE MODULATION RETINOID - RELATED ORPHAN RECEPTOR

The present invention is directed to novel retinoid-related orphan receptor gamma (RORy) modulators of formula (I), processes for their preparation, pharmaceutical compositions containing these modulators, and their use in the treatment of inflammatory, metabolic and autoimmune diseases mediated by RORy wherein R1 to R7 are as defined in claim 1.

Tritylation of tetrazole and 5-substituted tetrazoles with triphenylmethanol

-