3-(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-N-phenylacrylamide

Base Information

• Chemical Name: 3-(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-N-phenylacrylamide
• CAS No.: 1390681-84-1
• Molecular Formula: C₂₅H₂₁N₃O₂
• Molecular Weight: 395.461
• Mol file: 1390681-84-1.mol

Synonyms:3-(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-N-phenylacrylamide

Chemical Property of 3-(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-N-phenylacrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-N-phenylacrylamide

There total 3 articles about 3-(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-N-phenylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)acrylic acid (108446-75-9) + aniline (62-53-3) → 3-(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-N-phenylacrylamide (1390681-84-1)

Guidance literature:

With dmap; potassium carbonate; In dichloromethane; for 12h; Heating;

DOI:10.1016/j.bmc.2012.05.031

Reference yield:

phenylhydrazine hydrochloride (59-88-1) → 3-(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-N-phenylacrylamide (1390681-84-1)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium acetate / ethanol / 3 h / 50 - 60 °C

2: trichlorophosphate / 50 - 60 °C / Cooling

3: piperidine; pyridine / 5 h / 40 - 50 °C

4: dmap; potassium carbonate / dichloromethane / 12 h / Heating

With piperidine; pyridine; dmap; sodium acetate; potassium carbonate; trichlorophosphate; In ethanol; dichloromethane;

DOI:10.1016/j.bmc.2012.05.031

Reference yield:

3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxaldehyde (36640-42-3) → 3-(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-N-phenylacrylamide (1390681-84-1)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine; pyridine / 5 h / 40 - 50 °C

2: dmap; potassium carbonate / dichloromethane / 12 h / Heating

With piperidine; pyridine; dmap; potassium carbonate; In dichloromethane;

DOI:10.1016/j.bmc.2012.05.031

upstream raw materials:

phenylhydrazine hydrochloride

3-(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)acrylic acid

aniline

3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxaldehyde