36640-42-3

Basic information

• Product Name: 3-(4-METHOXY-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE
• Synonyms: 3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde(SALTDATA: FREE)
• CAS NO: 36640-42-3
• Molecular Formula: C₁₇H₁₄N₂O₂
• Molecular Weight: 278.31
• Mol File: 36640-42-3.mol
• Article Data: 97

Chemical Properties

• Boiling Point: 472.6°Cat760mmHg
• Flash Point: 239.6°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 4.21E-09mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 3-(4-METHOXY-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-METHOXY-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE(36640-42-3)
• EPA Substance Registry System: 3-(4-METHOXY-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE(36640-42-3)

Safety Data

• Hazardous Substances Data: 36640-42-3(Hazardous Substances Data)

Usage

Uses

3-(4-Methoxyphenyl)-1-phenyl-1h-pyrazole-4-carbaldehyde

InChI:InChI=1/C17H14N2O2/c1-21-16-9-7-13(8-10-16)17-14(12-20)11-19(18-17)15-5-3-2-4-6-15/h2-12H,1H3

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 24310-46-1 4-methoxyacetophenone phenylhydrazone 
• 3724-43-4 Vilsmeier reagent 
• 3471-32-7 4-Methoxyphenylhydrazine 
• 89671-57-8 1-(4'-methoxyphenyl)-2-(1''-phenylethylidene)hydrazine 
• 33064-21-0 3-(4-methoxy-phenyl)-1-phenyl-1H-pyrazole 
• 1400634-72-1 C₁₇H₁₅N₃O₂ 
• 622-73-1 4-methoxybenzaldehydephenylhydrazone 
• 100-63-0 phenylhydrazine 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 117788-17-7 (E)-1-(1-(4-methoxyphenyl)ethylidene)-2-phenylhydrazine 
• 18997-06-3 N,N-Dimethyl-formamide; compound with GENERIC INORGANIC NEUTRAL COMPONENT 
• 59-88-1 phenylhydrazine hydrochloride 

Downstream Products

• 108446-88-4 2-[3-(4-Methoxy-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid diethyl ester 
• 428840-36-2 1-phenyl-3-(4-methoxyphenyl)pyrazole-4-carboxaldehyde oxime 
• 313362-27-5 4-[3-(4-methoxy-phenyl)-1-phenyl-1H-pyrazol-4-yl]-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 
• 387846-67-5 1-phenyl-3-(4-methylphenyl)-1H-pyrazole-4-carboxaldehyde semicarbazone 
• 387847-38-3 1-phenyl-3-(4-methoxyphenyl)-1H-pyrazole-4-carboxaldehyde thiosemicarbazone 
• 387386-31-4 1-phenyl-3-(4-methoxyphenyl)-1H-pyrazole-4-carboxaldehyde phenylhydrazone 
• 313050-26-9 1-phenyl-3-[3-(4-methoxyphenyl)-1-phenyl-4-pyrazolyl]prop-2-en-1-one 
• 380456-99-5 C₂₆H₂₂N₂O₃ 
• 956373-73-2 2-[3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]-1,3-benzothiazole 
• 380912-76-5 C₂₃H₁₉N₃O₂ 
• 380912-86-7 C₂₃H₁₈ClN₃O₂ 
• 380895-02-3 C₂₃H₁₈BrN₃O₂ 
• 694435-37-5 C₂₄H₂₁N₃O₃ 
• 1380571-32-3 N-(4-ethoxyphenyl)-3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxamide 

Relevant articles and documents

Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities

As our ongoing work on lathyrane diterpenoid derivatization, three series of lathyrane diterpenoid derivatives were designed and synthesized based combination principles, including pyrazole, thiazole and furoxan moieties. Biological evaluation indicated t

Design, synthesis and in vitro antitumor evaluation of novel pyrazole-benzimidazole derivatives

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Design and synthesis of novel quinazolinone-pyrazole derivatives as potential α-glucosidase inhibitors: Structure-activity relationship, molecular modeling and kinetic study

In this study, a new series of quinazolinone-pyrazole hybrids were designed, synthesized and screened for their α-glucosidase inhibitory activity. The results of the in vitro screening indicated that all the molecular hybrids exhibited more inhibitory activity (IC50 values ranging from 60.5 ± 0.3 μM-186.6 ± 20 μM) in comparison to standard acarbose (IC50 = 750.0 ± 10.0 μM). Limited structure–activity relationship suggested that the variation in the inhibitory activities of the compounds affected by different substitutions on phenyl rings of diphenyl pyrazole moiety. The enzyme kinetic studies of the most potent compound 9i revealed that it inhibited α-glucosidase in a competitive mode with a Ki of 56 μM. Molecular docking study was performed to predict the putative binding interaction. As expected, all pharmacophoric moieties used in the initial structure design playing a pivotal role in the interaction with the binding site of the enzyme. In addition, by performing molecular dynamic investigation and MM-GBSA calculation, we investigated the difference in structural perturbation and dynamic behavior that is observed over α-glycosidase in complex with the most active compound and acarbose relative to unbound α-glycosidase enzyme.