DL-Glutamine

Base Information

• Chemical Name: DL-Glutamine
• CAS No.: 585-21-7
• Molecular Formula: C₅H₁₀N₂O₃
• Molecular Weight: 146.146
• Hs Code.: 2924199090
• Mol file: 585-21-7.mol

Synonyms:DL-Gln;DL-Glutamine;NSC 97925;

Chemical Property of DL-Glutamine

Chemical Property:

• Appearance/Colour: White needle crystal
• Melting Point: 186ºC
• Boiling Point: 445.6 °C at 760 mmHg
• Flash Point: 223.3 °C
• PSA: 106.41000
• Density: 1.321 g/cm³
• LogP: 0.06440
• Storage Temp.: Refrigerator
• Solubility.: Aqueous Acid (Slightly), Water (Slightly, Sonicated)

Purity/Quality:

99% ^*data from raw suppliers

DL-glutamIne ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-Glutamine

There total 12 articles about DL-Glutamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-phthalimidoglutaramic acid (7607-72-9,2110-19-2,174591-46-9) → GLUTAMINE (56-85-9,585-21-7,5959-95-5,6899-04-3,26700-71-0)

Guidance literature:

With hydrazine hydrate; In water; at 20 ℃; for 48h;

DOI:10.1016/j.molstruc.2020.128600

Reference yield:

→ GLUTAMINE (56-85-9,585-21-7,5959-95-5,6899-04-3,26700-71-0) + Glutamic acid (617-65-2,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6)

Guidance literature:

Reference yield:

N-phthalylglutamic acid (6349-98-0,2301-52-2) → GLUTAMINE (56-85-9,585-21-7,5959-95-5,6899-04-3,26700-71-0)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic anhydride / 0.25 h / Reflux

2: ammonia / 0.33 h / 20 °C

3: hydrazine hydrate / water / 48 h / 20 °C

With ammonia; acetic anhydride; hydrazine hydrate; In water;

DOI:10.1016/j.molstruc.2020.128600

upstream raw materials:

6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid

L-glutamine

theanyl-L-alanine (H-Tea-L-Ala-OH)

ammonia

Downstream raw materials:

N-benzoylglutamine

2-(5-Benzyl-6-thioxo-[1,3,5]thiadiazinan-3-yl)-4-carbamoyl-butyric acid

3-(2-Phenylethyl)-5-<α-(2-carbamidoethyl)carboxymethyl>-tetrahydro-2H-1,3,5-thiadiazine-2-thione

t-Bumeoc-Gln

Refernces

• 1、 Bayer, Ernst. "Chiral Recognition of Natural Products on Optically Active Polysiloxanes". . p. 1281 - 1291. Retrieved 2007/10/02.
• 2、 -. "Process for obtaining amino acids from the raw juices of sugar manufacture". . . Retrieved 2008/06/13.