N-benzyloxycarbonyl-glycine-<4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)>piperidinamide

Base Information

Chemical Name:N-benzyloxycarbonyl-glycine-<4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)>piperidinamide
CAS No.:78734-42-6
Molecular Formula:C₂₂H₂₄N₄O₄
Molecular Weight:408.457
Hs Code.:

Synonyms:N-benzyloxycarbonyl-glycine-<4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)>piperidinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-benzyloxycarbonyl-glycine-<4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)>piperidinamide

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Technology Process of N-benzyloxycarbonyl-glycine-<4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)>piperidinamide

There total 1 articles about N-benzyloxycarbonyl-glycine-<4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)>piperidinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.8%

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 20662-53-7
4-(2-keto-1-benzimidazolinyl)piperidine

: 78734-42-6
N-benzyloxycarbonyl-glycine-<4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)>piperidinamide

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; for 4h;
DOI:10.1248/cpb.30.474

Reference yield:

: 78734-42-6
N-benzyloxycarbonyl-glycine-<4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)>piperidinamide

: 78734-36-8
3,4-dihydroxyphenyl-2-methyl-L-alanylglycine<4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)>piperidinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 95.1 percent / H₂, HCl / Pd/C / methanol / 4.5 h

2: 45.3 percent / DCC, Et₃N / CH₂Cl₂ / 1.5 h / 0 °C

3: 99.1 percent / H₂, HCl / Pd/C / methanol

With hydrogenchloride; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1248/cpb.30.474

Reference yield:

: 78734-42-6
N-benzyloxycarbonyl-glycine-<4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)>piperidinamide

: 78734-35-7
N-benzyloxycarbonyl-3,4-dibenzyloxycarbonyloxyphenyl-2-methyl-L-alanyl-glycine<4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)>piperidinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 95.1 percent / H₂, HCl / Pd/C / methanol / 4.5 h

2: 45.3 percent / DCC, Et₃N / CH₂Cl₂ / 1.5 h / 0 °C

With hydrogenchloride; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1248/cpb.30.474