(S)-2-(1-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-tert-butoxyacetic acid

Base Information

Chemical Name:(S)-2-(1-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-tert-butoxyacetic acid
CAS No.:1354186-28-9
Molecular Formula:C₃₉H₃₇ClN₂O₆
Molecular Weight:665.186
Hs Code.:

Synonyms:(S)-2-(1-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-tert-butoxyacetic acid

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Chemical Property of (S)-2-(1-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-tert-butoxyacetic acid

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Technology Process of (S)-2-(1-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-tert-butoxyacetic acid

There total 19 articles about (S)-2-(1-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-tert-butoxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354189-98-2
C₃₉H₃₇ClN₂O₅

: 1354186-28-9
(S)-2-(1-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-tert-butoxyacetic acid

Guidance literature:: C₃₉H₃₇ClN₂O₅; With sodium chlorite; sodium dihydrogenphosphate; In acetonitrile; for 1.5h;

With hydrogenchloride; In water; acetonitrile; pH=5;

Reference yield:

: 50741-92-9
2-methyl-4-nitroanisole

: 1354186-28-9
(S)-2-(1-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-tert-butoxyacetic acid

Guidance literature:: Multi-step reaction with 18 steps

1.1: tin(II) chloride dihdyrate / triphenylphosphine; rhodium(III) chloride hydrate / isopropyl alcohol; 1,4-dioxane; water / 20 h / 180 °C / Inert atmosphere

2.1: N-Bromosuccinimide; sulfuric acid / 3.5 h / 15 °C

2.2: pH 10 / Cooling with ice

3.1: boron tribromide / dichloromethane / 3 h

3.2: 0.33 h / 0 °C

4.1: pyridine / dichloromethane / 2 h / -30 - 0 °C

5.1: lithium chloride / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

6.1: hydroquinine 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 48 h / 0 °C

7.1: pyridine / dichloromethane / 12 h / 0 - 20 °C

8.1: perchloric acid / 2 h / 25 °C

9.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h

10.1: 10 h / 140 °C

11.1: methylamine / ethanol; water / 1.33 h / 78 °C

12.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1.5 h / 100 °C

13.1: sodium hydroxide; methanol / tetrahydrofuran / 16 h / 25 °C

14.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

15.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h

15.2: 20 °C

16.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

16.2: 0 - 20 °C

17.1: Dess-Martin periodane / dichloromethane / 1.5 h / 20 °C

18.1: sodium chlorite; sodium dihydrogenphosphate / acetonitrile / 1.5 h

18.2: pH 5

With pyridine; 1H-imidazole; methanol; sodium chlorite; sodium dihydrogenphosphate; N-Bromosuccinimide; perchloric acid; tin(II) chloride dihdyrate; hydroquinine 1,4-phthalazinediyl diether; sulfuric acid; potassium tert-butylate; tetrabutyl ammonium fluoride; boron tribromide; potassium carbonate; Dess-Martin periodane; 3-chloro-benzenecarboperoxoic acid; methylamine; lithium chloride; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; rhodium(III) chloride hydrate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; tert-butyl alcohol;

Reference yield:

: 467219-83-6
6-methoxy-7-methylquinoline

: 1354186-28-9
(S)-2-(1-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-tert-butoxyacetic acid

Guidance literature:: Multi-step reaction with 17 steps

1.1: N-Bromosuccinimide; sulfuric acid / 3.5 h / 15 °C

1.2: pH 10 / Cooling with ice

2.1: boron tribromide / dichloromethane / 3 h

2.2: 0.33 h / 0 °C

3.1: pyridine / dichloromethane / 2 h / -30 - 0 °C

4.1: lithium chloride / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

5.1: hydroquinine 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 48 h / 0 °C

6.1: pyridine / dichloromethane / 12 h / 0 - 20 °C

7.1: perchloric acid / 2 h / 25 °C

8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h

9.1: 10 h / 140 °C

10.1: methylamine / ethanol; water / 1.33 h / 78 °C

11.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1.5 h / 100 °C

12.1: sodium hydroxide; methanol / tetrahydrofuran / 16 h / 25 °C

13.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

14.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h

14.2: 20 °C

15.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

15.2: 0 - 20 °C

16.1: Dess-Martin periodane / dichloromethane / 1.5 h / 20 °C

17.1: sodium chlorite; sodium dihydrogenphosphate / acetonitrile / 1.5 h

17.2: pH 5

With pyridine; 1H-imidazole; methanol; sodium chlorite; sodium dihydrogenphosphate; N-Bromosuccinimide; perchloric acid; hydroquinine 1,4-phthalazinediyl diether; sulfuric acid; potassium tert-butylate; tetrabutyl ammonium fluoride; boron tribromide; potassium carbonate; Dess-Martin periodane; 3-chloro-benzenecarboperoxoic acid; methylamine; lithium chloride; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;