50741-92-9

Usage

Uses

Used in Chemical Synthesis:
2-METHYL-4-NITROANISOLE 97 is used as an intermediate in the synthesis of various chemical compounds for different applications. It serves as a key component in the production of 2-methyl-4-nitrophenol and 3-methyl-4-methoxyaniline, which can be utilized in further chemical reactions and processes.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-METHYL-4-NITROANISOLE 97 may be used as a starting material for the development of new drugs or drug candidates. Its unique chemical structure can be modified and optimized to create potential therapeutic agents for various medical conditions.
Used in Dye and Pigment Industry:
2-METHYL-4-NITROANISOLE 97 can also be employed in the dye and pigment industry as a precursor for the synthesis of various organic dyes and pigments. These dyes and pigments can be used in a wide range of applications, including textiles, plastics, and printing inks.
Used in Research and Development:
Due to its unique chemical properties, 2-METHYL-4-NITROANISOLE 97 can be utilized in research and development for the exploration of new chemical reactions, mechanisms, and processes. It can serve as a valuable tool for scientists and researchers in understanding the behavior of similar compounds and developing new methodologies in organic chemistry.

Upstream product

• 578-58-5 2-methylmethoxybenzene 
• 13290-74-9 1-chloro-2-methyl-4-nitrobenzene 
• 124-41-4 sodium methylate 
• 861609-39-4 2-methoxy-3-methyl-5-nitro-aniline 
• 99-53-6 2-methyl-4-nitrophenol 
• 77-78-1 dimethyl sulfate 
• 86771-76-8 2-nitro-4-methyl-5-methoxy aniline 
• 186581-53-3 diazomethane 
• 509-14-8 tetranitromethane 
• 3913-23-3 2-methoxy-5-nitrobenzyl bromide 
• 74-88-4 methyl iodide 
• 56-23-5 tetrachloromethane 
• 455-88-9 5-nitro-2-fluorotoluene 
• 6880-04-2 4-methoxy-3-methylbenzoic acid 

Downstream Products

• 99-53-6 2-methyl-4-nitrophenol 
• 14786-82-4 4-hydroxy-2-methylanisole 
• 29027-13-2 2-methyl-4,6-dinitroanisole 
• 40751-89-1 2-methoxy-5-nitrobenzoic acid 
• 31910-25-5 N-(4-methoxy-3-methylphenyl)acetamide 
• 136-90-3 4-methoxy-3-methylaniline 
• 328400-86-8 2-bromo-4-methoxy-5-methylaniline 
• 1354189-98-2 C₃₉H₃₇ClN₂O₅ 
• 1354189-97-1 (S)-(9H-fluoren-9-yl)methyl 2-(6-(1-tert-butoxy-2-hydroxyethyl)-5-(4-chlorophenyl)-7-methyl-2-oxoquinolin-1(2H)-yl)ethylcarbamate 
• 1354189-95-9 (S)-2-(trimethylsilyl)ethyl 2-(6-(1-tert-butoxy-2-(tert-butyldimethylsilyloxy)ethyl)-5-(4-chlorophenyl)-7-methyl-2-oxoquinolin-1(2H)-yl)ethylcarbamate 
• 1354189-92-6 (S)-6-(1-tert-butoxy-2-(tert-butyldimethylsilyloxy)ethyl)-5-(4-chlorophenyl)-7-methylquinolin-2(1H)-one 
• 1354186-28-9 (S)-2-(1-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-tert-butoxyacetic acid 
• 1354189-70-0 (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-7-methylquinolin-6-yl)ethanol 
• 1354189-68-6 (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-7-methylquinolin-6-yl)ethyl pivalate 

Relevant academic research and scientific papers

Eco-Friendly Methodology for the Formation of Aromatic Carbon–Heteroatom Bonds by Using Green Ionic Liquids

A new sustainable method is reported for the formation of aromatic carbon–heteroatom bonds under solvent-free and mild conditions (no co-oxidant, no strong acid and no toxic reagents) by using a new type of green ionic liquid. The bromination of methoxy arenes was chosen as a model reaction. The reaction methodology is based on only using natural sodium bromine, which is transformed into an electrophilic brominating reagent within an ionic liquid, easily prepared from the melted salt FeCl3 hexahydrate. Bromination reactions with this in-situ-generated reagent gave good yields and excellent regioselectivity under simple and environmentally friendly conditions. To understand the unusual bromine polarity reversal of sodium bromine without any strong oxidant, the molecular structure of the reaction medium was characterised by Raman and direct infusion electrospray ionisation mass spectroscopy (ESI-MS). An extensive computational investigation using density functional theory methods was performed to describe a mechanism that suggests indirect oxidation of Br? through new iron adducts. The versatility of the methodology was successively applied to nitration and thiocyanation of methoxy arenes using KNO3 and KSCN in melted hexahydrated FeCl3.

Enantioselective Synthesis of (+)-Mitomycin K by a Palladium-Catalyzed Oxidative Tandem Cyclization

The mitomycins, a family of bioactive natural products, feature a compact 6/5/5-fused polycyclic ring structure densely decorated with highly reactive and/or fragile quinone, amino ketal, and aziridine as well as carbamate moieties. It is this striking feature that has defeated numerous synthetic attempts towards these apparently small molecules, rendering them one of the most formidable targets for total synthesis. We herein report the first enantioselective synthesis of (+)-mitomycin K, a representative of G series mitomycins. The key step of this synthesis is an enantioselective oxidative cyclization catalyzed by a palladium/(+)-sparteine system that had previously been developed by our group. The robustness of this method bodes well for further applications in the asymmetric total synthesis of natural products, particularly those with characteristic 6/5/5-fused pyrroloindole skeletons.

Triton B-mediated efficient and convenient alkoxylation of activated aryl and heteroaryl halides

A simple and convenient one-pot synthesis of aryl alkyl ethers by the alkoxylation of aryl halides with alcohol in the presence of Triton B as a base is described. The procedure is applicable for a variety of aryl and heteroaryl halides, and yields are very good. The use of a nonmetallic base and solvent-free conditions are important features of the reaction. Copyright Taylor & Francis Group, LLC.

(AZA)INDOLE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES

The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level which has a uricosuric activity or the like. The present invention relates to (aza)indole derivatives represented by the following general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In the formula (I), T represents nitro or cyano and the like; ring J represents aryl or heteroaryl and the like; Q represents carboxy or 5-tetazolyl and the like; Y represents H, OH, NH2, halogen, nitro, alkyl, alkoxy and the like; X1, X2 and X3 independently represent CR2 or N; R1 and R2 independently represent halogen, cyano, haloalkyl, A-D-E-G, -N(-D-E-G)2 and the like, in the formula, A represents a single bond, O, S and the like; D and G independently represent optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene and the like; E represents a single bond, O, S, COO, SO2 and the like.

Nitration of some aromatic compounds by sodium nitrate in the presence of benzyltriphenylphosphonium peroxodisulfate

A simple, mild, and regioselective method for the nitration of some aromatic compounds using sodium nitrate in the presence of benzyltriphenylphosphonium peroxodisulfate in acetonitrile as solvent is reported. Mild reaction conditions and good to excellent yields of the products are the noteworthy advantages of the method. Copyright Taylor & Francis Group, LLC.

BENZOTRIAZEPINONE DERIVATIVES

The present invention is concerned with benzotriazepinone derivatives, their intermediates, uses thereof and processes for their production. In particular, the present invention relates to parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrp) receptor ligands, (PTH-I or PTH/PTHrp receptor ligands). The invention also relates to methods of preparing such ligands and to compounds which are useful as intermediates in such methods.

2- (4-0X0-4H-QUINAZ0LIN-3-YL) ACETAMIDES AND THEIR USE AS VASOPRESSIN V3 ANTAGONISTS

The present invention relates to 2-(4-oxo4H-quinazolin-3-yl)acetamicle derivatives of formula (I), and to their use as vasopressin V3 antagonists, particularly for the treatment of depression.

1,2-disubstituted 1,4-dihydro-4-oxoquinoline compounds

The present invention relates to substituted 1,4-dihydro-4-oxoquinolines having antiviral activity. The substituents are present at positions 1, 2 and at least one of 5-8 positions of the quinoline ring.

Photochemical nitration by tetranitromethane. Part XXXVII. Adduct formation and the regiochemistry of attack of trinitromethanide ion on radical cations in the photochemical reactions of 2-methyl-, 2,3-dimethyl- and 2,4-Dimethylanisoles

The photolysis of the charge transfer (CT) complex of tetranitromethane and 2-methylanisole 2 in dichloromethane at 20 °C gives the epimeric 1-methoxy-6-methyl-6-nitro-3-trinitromethylcyclohexa-1,4-dienes 8 and 9 in addition to 2-methyl-4-trinitromethylanisole (3) and 2-methyl-4-nitroanisole (4). In acetonitrile the yields of compound 4 and adducts 8 and 9 are significantly higher. Similar reaction of 2,3-dimethylanisole (6) in dichloromethane gave nitro-trinitromethyl adducts 10 and 11, hydroxy-trinitromethyl adducts 12 and 13, 2,3-dimethyl-5-trinitromethylanisole (14), 4-methoxy-2,3-dimethylbenzonitrile N-oxide (15), 2,3-dimethyl-4-trinitromethylanisole (16), 2,3-dimethyl-4-nitroanisole (17), 2,3-dimethyl-4,6-dinitrophenol (18), 3-methoxy-4,5-dimethyl-benzoic acid (19) and the hydroxy dinitro compound (20). The photolysis of the CT complex of 2,4-dimethylanisole (7) with tetranitromethane in dichloromethane gave the epimeric 1-methoxy-4,6-dimethyl-6-nitro-3-trinitromethylcyclohexa-1,4-dienes 21 and 22, together with 4,6-dimethyl-3-trinitromethylanisole (23), 4,6-dimethyl-2-nitrophenol (24), 4,6-dimethyl-2-trinitromethylanisole (25), 4,6-dimethyl-3-nitroanisole (26), 4,6-dimethyl-2-nitroanisole (27) and 4,6-dimethyl-4-nitrocyclohexa-2,5-dienone (28). The modes of formation of the above products are discussed, including the effects of the reaction solvent on those processes. The X-ray crystal structure of 1-methoxy-2-methyl-c-6-nitro-r-3-trinitromethylcyclohexa-1,4-diene (9) is reported. Acta Chemica Scandinavica 1997.

Thermal and photochemical decomposition pathways of trinitromethylarenes. part II. The effects of ethanol on the photolysis reactions of some alkoxy- and dialkoxyarenes in the presence of tetranitromethane. enhancement of adduct and trinitromethyl substitution product formation

The photolysis of the charge transfer (CT) complex of tetranitromethane with 1-methoxynaphthalene, 1,4-dimethoxybenzene, 1,2-dimethoxybenzene, 1,2-methylenedioxybenzene or 2-methylanisole is reported for dichloromethane, acetonitrile, dichloromethane-ethanol and acetonitrile-ethanol solvent systems. The effects of adding ethanol (8% v/v ? 1.4 mol dm-3) to dichloromethane or acetonitrile as reaction solvents include: (i) the stabilization of alkoxytrinitro-methylarenes, thus reducing their normal tendency for decomposition according to ArC (NO2)3→ArCOOH→ArNO2, (ii) a reduction in the nucleophilicity of trinitromethanide ion, and (iii) changes in the regioselectivity of trinitromethanide ion attack on the radical cations of alkoxyaromatic compounds away from attack ipso to the alkoxy substituent. Adducts are also stabilized, as shown by the photolysis of the CT complex of 1,4-dimethoxybenzene-tetranitromethane in dichloromethane-ethanol (8% v/v) which gives the epimeric 1,4-dimethoxy-3-nitro-6-trinitromethylcyclohexa-1,4-dienes and 1,4-dimethoxy-2-trinitromethylbenzene, in addition to 1,4-dimethoxy-2-nitrobenzene. The adducts are detected also among the products of photolysis reactions in neat dichloromethane or acetonitrile. Acta Chemica Scandinavica 1997.