(S)-2-methyl-2-propanesulfinic acid 3-cyclopropylmethoxy-4-(difluoromethoxy)benzylideneamide

Base Information

Chemical Name:(S)-2-methyl-2-propanesulfinic acid 3-cyclopropylmethoxy-4-(difluoromethoxy)benzylideneamide
CAS No.:1367625-79-3
Molecular Formula:C₁₆H₂₁F₂NO₃S
Molecular Weight:345.41
Hs Code.:

Synonyms:(S)-2-methyl-2-propanesulfinic acid 3-cyclopropylmethoxy-4-(difluoromethoxy)benzylideneamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-methyl-2-propanesulfinic acid 3-cyclopropylmethoxy-4-(difluoromethoxy)benzylideneamide

Chemical Property:

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Technology Process of (S)-2-methyl-2-propanesulfinic acid 3-cyclopropylmethoxy-4-(difluoromethoxy)benzylideneamide

There total 1 articles about (S)-2-methyl-2-propanesulfinic acid 3-cyclopropylmethoxy-4-(difluoromethoxy)benzylideneamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.8%

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: 151103-09-2
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

: 1367625-79-3
(S)-2-methyl-2-propanesulfinic acid 3-cyclopropylmethoxy-4-(difluoromethoxy)benzylideneamide

Guidance literature:: With titanium(IV) tetraethanolate; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1039/c2ob06495b

Reference yield: 83.0%

: 108-89-4
picoline

: 1367625-79-3
(S)-2-methyl-2-propanesulfinic acid 3-cyclopropylmethoxy-4-(difluoromethoxy)benzylideneamide

: 1367625-82-8
(S,S)-2-methyl-2-propanesulfinic acid [1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)ethyl]amide

Guidance literature:: picoline; With n-butyllithium; In tetrahydrofuran; at -78 - 0 ℃; for 0.5h;

(S)-2-methyl-2-propanesulfinic acid 3-cyclopropylmethoxy-4-(difluoromethoxy)benzylideneamide; In tetrahydrofuran; at -78 ℃; for 3h; optical yield given as %de;
DOI:10.1039/c2ob06495b

Reference yield:

: 1367625-79-3
(S)-2-methyl-2-propanesulfinic acid 3-cyclopropylmethoxy-4-(difluoromethoxy)benzylideneamide

: 1367625-88-4
(S)-4-{2-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-[3-(3-nitrophenyl)pyrazol-1-yl]ethyl}pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 - 0 °C

1.2: 3 h / -78 °C

2.1: hydrogenchloride / 1,4-dioxane; water / 0 - 20 °C

3.1: ethanol / 12 h / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

4.2: 3.17 h / 0 °C / Heating

With hydrogenchloride; n-butyllithium; sodium hydride; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1039/c2ob06495b