3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol; compound with oxalic acid

Base Information

Chemical Name:3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol; compound with oxalic acid
CAS No.:115562-25-9
Molecular Formula:C₂H₂O₄*2C₉H₁₂FNO₃
Molecular Weight:492.431
Hs Code.:

Synonyms:3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol; compound with oxalic acid

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Chemical Property of 3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol; compound with oxalic acid

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Technology Process of 3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol; compound with oxalic acid

There total 7 articles about 3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol; compound with oxalic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 144-62-7,97993-78-7
oxalic acid

: 115562-23-7
1-(3,4-Bis-benzyloxy-2-fluoro-phenyl)-2-methylamino-ethanol

: 115562-25-9
3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol; compound with oxalic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 6h; under 2068.6 Torr;
DOI:10.1021/jm00118a019

Reference yield:

: 37686-68-3
2-fluoro-3,4-dimethoxybenzaldehyde

: 115562-25-9
3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol; compound with oxalic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) BBr₃

3: LiAlH₄

4: 83 percent / 4 h / Heating

5: 46 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

6: 87 percent / H₂ / 10percent Pd/C / methanol / 6 h / 2068.6 Torr

With lithium aluminium tetrahydride; hydrogen; boron tribromide; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm00118a019

Reference yield:

: 394-64-9
1-fluoro-2,3-dimethoxybenzene

: 115562-25-9
3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol; compound with oxalic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 74 percent / TiCl₄ / CH₂Cl₂ / 0 deg C, 0.5 h; RT, 4.5 h

2: 1.) BBr₃

4: LiAlH₄

5: 83 percent / 4 h / Heating

6: 46 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

7: 87 percent / H₂ / 10percent Pd/C / methanol / 6 h / 2068.6 Torr

With lithium aluminium tetrahydride; hydrogen; boron tribromide; titanium tetrachloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00118a019