2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Base Information

Chemical Name:2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide
CAS No.:154753-60-3
Molecular Formula:C₂₆H₂₅F₃N₄O₅
Molecular Weight:530.504
Hs Code.:

Synonyms:2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

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Chemical Property of 2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

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Technology Process of 2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

There total 9 articles about 2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-43-6
dichloro-acetic acid

: 1-(3-dimethylaminopropyl)-3-ethylcarbodimide

: 148747-60-8
2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

: 154753-60-3
2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Guidance literature:: With dimethyl sulfoxide; In toluene;

Reference yield:

: 139721-85-0
α-chlorophenylformamidine hydrochloride

: 154753-60-3
2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: methanol / 72 h / 5 °C

2: methanol / 1.5 h / 100 °C

3: pyridine, lithium iodide / 2 h / Heating

4: 1.) Et₃N, diphenyl phosphorazidate / 1.) 100 deg C, 2 h, 2.) 100 deg C, 12 h

5: 1N aq. HCl / tetrahydrofuran / 8 h / Heating

6: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s) / 1 h / Ambient temperature

7: 1-hydroxybenzotriazole hydrate, Et₃N, EDC / dimethylformamide / 16 h

With pyridine; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; diphenyl phosphoryl azide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxybenzotriazol-hydrate; triethylamine; lithium iodide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm00001a015

Reference yield:

: 100-47-0
benzonitrile

: 154753-60-3
2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: HCl / ethanol / 16 h / Ambient temperature

2: methanol / 72 h / 5 °C

3: methanol / 1.5 h / 100 °C

4: pyridine, lithium iodide / 2 h / Heating

5: 1.) Et₃N, diphenyl phosphorazidate / 1.) 100 deg C, 2 h, 2.) 100 deg C, 12 h

6: 1N aq. HCl / tetrahydrofuran / 8 h / Heating

7: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s) / 1 h / Ambient temperature

8: 1-hydroxybenzotriazole hydrate, Et₃N, EDC / dimethylformamide / 16 h

With pyridine; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; diphenyl phosphoryl azide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxybenzotriazol-hydrate; triethylamine; lithium iodide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm00001a015