2-Chloro-1-fluoro-3-(methoxymethoxy)benzene

Base Information

Chemical Name:2-Chloro-1-fluoro-3-(methoxymethoxy)benzene
CAS No.:860296-13-5
Molecular Formula:C₈H₈ClFO₂
Molecular Weight:190.602
Hs Code.:
DSSTox Substance ID:DTXSID501260563

Synonyms:2-chloro-1-fluoro-3-(methoxymethoxy)benzene;860296-13-5;Benzene, 2-chloro-1-fluoro-3-(methoxymethoxy)-;SCHEMBL21246882;DTXSID501260563;MFCD30178333;AKOS024263173;CS-0193124;E94440

Suppliers and Price of 2-Chloro-1-fluoro-3-(methoxymethoxy)benzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-Chloro-1-fluoro-3-(methoxymethoxy)benzene

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:190.0196853
Heavy Atom Count:12
Complexity:134

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COCOC1=C(C(=CC=C1)F)Cl

Technology Process of 2-Chloro-1-fluoro-3-(methoxymethoxy)benzene

There total 2 articles about 2-Chloro-1-fluoro-3-(methoxymethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 126940-10-1
1-fluoro-3-(methoxy-methoxy)benzene

: 860296-13-5
2-chloro-1-fluoro-3-(methoxymethoxy)benzene

Guidance literature:: 1-fluoro-3-(methoxy-methoxy)benzene; With sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -75 ℃; for 2h;

With 1,1,2-Trichloro-1,2,2-trifluoroethane; In tetrahydrofuran; cyclohexane; at -75 ℃; for 0.75h;
DOI:10.1002/ejoc.200400895

Reference yield:

: 372-20-3
3-fluorophenol

: 860296-13-5
2-chloro-1-fluoro-3-(methoxymethoxy)benzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / -78 °C / Inert atmosphere

2.2: 0.17 h / -78 °C

With sec.-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; cyclohexane;

Reference yield: 73.0%

: 860296-13-5
2-chloro-1-fluoro-3-(methoxymethoxy)benzene

: 124-38-9,18923-20-1
carbon dioxide

: 860296-15-7
3-chloro-2-fluoro-4-hydroxybenzoic acid

Guidance literature:: 2-chloro-1-fluoro-3-(methoxymethoxy)benzene; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; at -75 ℃; for 2h;

carbon dioxide; In tetrahydrofuran; hexane;

With hydrogenchloride; In water; pH=1;
DOI:10.1002/ejoc.200400895