Benzoic acid (2R,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester; compound with triethyl-amine

Base Information

• Chemical Name: Benzoic acid (2R,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester; compound with triethyl-amine
• CAS No.: 81352-50-3
• Molecular Formula: C₆H₁₅N*C₅₀H₄₁ClN₅O₁₀P
• Molecular Weight: 1039.52
• Mol file: 81352-50-3.mol

Synonyms:Benzoic acid (2R,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester; compound with triethyl-amine

Chemical Property of Benzoic acid (2R,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester; compound with triethyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid (2R,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester; compound with triethyl-amine

There total 1 articles about Benzoic acid (2R,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester; compound with triethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,O-Dibenzoyl-6,3' O-monomethoxytrityl-5' β-D-xylofurannosyl-9 adenine (81352-48-9) + 2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide) (72351-28-1) → Benzoic acid (2R,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester; compound with triethyl-amine (81352-50-3)

Guidance literature:

With triethylamine; Yield given. Multistep reaction; 1.) acetonitrile-pyridine 2.) H₂O;

DOI:10.1016/S0040-4039(01)83016-1

Reference yield: 75.0%

C61H48ClN10O15P (81352-23-0) + Benzoic acid (2R,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester; compound with triethyl-amine (81352-50-3) → C111H87Cl2N15O24P2 (81352-24-1)

Guidance literature:

With 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; In pyridine; for 0.333333h; Ambient temperature;

DOI:10.1016/S0040-4039(01)83016-1

Reference yield:

Benzoic acid (2R,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester; compound with triethyl-amine (81352-50-3) + N6-benzoyl-9-(2,3-di-O-benzoyl-β-D-xylofuranosyl)adenine (31079-98-8) → C81H64ClN10O16P (81352-51-4)

Guidance literature:

With 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; In pyridine; for 0.333333h; Ambient temperature;

DOI:10.1016/S0040-4039(01)83016-1

upstream raw materials:

N,O-Dibenzoyl-6,3' O-monomethoxytrityl-5' β-D-xylofurannosyl-9 adenine

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide)

Downstream raw materials:

C₁₁₁H₈₇Cl₂N₁₅O₂₄P₂

C₈₁H₆₄ClN₁₀O₁₆P