[9-((2R,3R,4R,5R)-4-{11-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-undecyloxy}-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-trityl-amine

Base Information

• Chemical Name: [9-((2R,3R,4R,5R)-4-{11-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-undecyloxy}-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-trityl-amine
• CAS No.: 191853-36-8
• Molecular Formula: C₈₆H₉₅N₅O₅Si
• Molecular Weight: 1306.82
• Mol file: 191853-36-8.mol

Synonyms:[9-((2R,3R,4R,5R)-4-{11-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-undecyloxy}-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-trityl-amine

Chemical Property of [9-((2R,3R,4R,5R)-4-{11-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-undecyloxy}-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-trityl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [9-((2R,3R,4R,5R)-4-{11-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-undecyloxy}-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-trityl-amine

There total 3 articles about [9-((2R,3R,4R,5R)-4-{11-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-undecyloxy}-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-trityl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(11-bromoundecyloxy)dimethyl(1,1,2-trimethylpropyl)silane (191853-33-5) + (2R,3R,4R,5R)-5-(6-(tritylamino)-9H-purin-9-yl)-4-(trityloxy)-2-((trityloxy)methyl)tetrahydrofuran-3-ol (31085-56-0) → [9-((2R,3R,4R,5R)-4-{11-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-undecyloxy}-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-trityl-amine (191853-36-8)

Guidance literature:

With sodium hydride; sodium iodide; In acetonitrile; 1.) room temp., 20 min.; 2.) room temp. overnight;

DOI:10.1002/hlca.19970800313

Reference yield:

1-Bromo-11-hydroxyundecane (1611-56-9) → [9-((2R,3R,4R,5R)-4-{11-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-undecyloxy}-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-trityl-amine (191853-36-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / 1H-imidazole / tetrahydrofuran

2: 88 percent / 1.) NaH; 2.) NaI / acetonitrile / 1.) room temp., 20 min.; 2.) room temp. overnight

With 1H-imidazole; sodium hydride; sodium iodide; In tetrahydrofuran; acetonitrile;

DOI:10.1002/hlca.19970800313

Reference yield:

chlorodimethyl(1,1,2-trimethylpropyl)silane (67373-56-2) → [9-((2R,3R,4R,5R)-4-{11-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-undecyloxy}-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-trityl-amine (191853-36-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / 1H-imidazole / tetrahydrofuran

2: 88 percent / 1.) NaH; 2.) NaI / acetonitrile / 1.) room temp., 20 min.; 2.) room temp. overnight

With 1H-imidazole; sodium hydride; sodium iodide; In tetrahydrofuran; acetonitrile;

DOI:10.1002/hlca.19970800313

upstream raw materials:

(11-bromoundecyloxy)dimethyl(1,1,2-trimethylpropyl)silane

(2R,3R,4R,5R)-5-(6-(tritylamino)-9H-purin-9-yl)-4-(trityloxy)-2-((trityloxy)methyl)tetrahydrofuran-3-ol

1-Bromo-11-hydroxyundecane

chlorodimethyl(1,1,2-trimethylpropyl)silane

Downstream raw materials:

11-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-undecan-1-ol

4-Oxo-pentanoic acid 11-((2R,3S,4R,5R)-4-hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-undecyl ester

4-Oxo-pentanoic acid 11-{(2R,3R,4R,5R)-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxycarbonyloxy]-tetrahydro-furan-3-yloxy}-undecyl ester

4-Oxo-pentanoic acid 11-((2R,3S,4R,5R)-4-hydroxy-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-undecyl ester