4-Oxo-pentanoic acid 11-{(2R,3R,4R,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxycarbonyloxy]-tetrahydro-furan-3-yloxy}-undecyl ester

Base Information

Chemical Name:4-Oxo-pentanoic acid 11-{(2R,3R,4R,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxycarbonyloxy]-tetrahydro-furan-3-yloxy}-undecyl ester
CAS No.:191853-62-0
Molecular Formula:C₆₄H₇₁N₇O₁₆
Molecular Weight:1194.31
Hs Code.:

4-Oxo-pentanoic acid 11-{(2R,3R,4R,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxycarbonyloxy]-tetrahydro-furan-3-yloxy}-undecyl ester

Synonyms:4-Oxo-pentanoic acid 11-{(2R,3R,4R,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxycarbonyloxy]-tetrahydro-furan-3-yloxy}-undecyl ester

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Chemical Property of 4-Oxo-pentanoic acid 11-{(2R,3R,4R,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxycarbonyloxy]-tetrahydro-furan-3-yloxy}-undecyl ester

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Technology Process of 4-Oxo-pentanoic acid 11-{(2R,3R,4R,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxycarbonyloxy]-tetrahydro-furan-3-yloxy}-undecyl ester

There total 11 articles about 4-Oxo-pentanoic acid 11-{(2R,3R,4R,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxycarbonyloxy]-tetrahydro-furan-3-yloxy}-undecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1-methyl-3-p-nitrobenzyloxycarbonylimidazolium chloride

: 191853-58-4
4-Oxo-pentanoic acid 11-((2R,3S,4R,5R)-4-hydroxy-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-undecyl ester

: 191853-62-0
4-Oxo-pentanoic acid 11-{(2R,3R,4R,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxycarbonyloxy]-tetrahydro-furan-3-yloxy}-undecyl ester

Guidance literature:: With dmap; In dichloromethane; Ambient temperature;
DOI:10.1002/hlca.19970800313

Reference yield:

: 1611-56-9
1-Bromo-11-hydroxyundecane

: 191853-62-0
4-Oxo-pentanoic acid 11-{(2R,3R,4R,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxycarbonyloxy]-tetrahydro-furan-3-yloxy}-undecyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 68 percent / 1H-imidazole / tetrahydrofuran

2: 88 percent / 1.) NaH; 2.) NaI / acetonitrile / 1.) room temp., 20 min.; 2.) room temp. overnight

3: 94 percent / Bu₄NF*3H₂O / tetrahydrofuran / Ambient temperature

4: 86 percent / EDC*HCl, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

5: 86 percent / 80percent AcOH / H₂O / 0.5 h / 100 °C

6: (NH₂₄)SO₄ / dioxane / 3 h / Heating

7: CH₂Cl₂

8: 80percent AcOH / H₂O / 1 h

9: 74 percent / pyridine / 24 h / Ambient temperature

10: 89 percent / DMAP / CH₂Cl₂ / Ambient temperature

With pyridine; 1H-imidazole; dmap; (NH₂₄)SO₄; tetrabutyl ammonium fluoride; sodium hydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;
DOI:10.1002/hlca.19970800313

Reference yield:

: 123-76-2
levulinic acid

: 191853-62-0
4-Oxo-pentanoic acid 11-{(2R,3R,4R,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxycarbonyloxy]-tetrahydro-furan-3-yloxy}-undecyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / EDC*HCl, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

2: 86 percent / 80percent AcOH / H₂O / 0.5 h / 100 °C

3: (NH₂₄)SO₄ / dioxane / 3 h / Heating

4: CH₂Cl₂

5: 80percent AcOH / H₂O / 1 h

6: 74 percent / pyridine / 24 h / Ambient temperature

7: 89 percent / DMAP / CH₂Cl₂ / Ambient temperature

With pyridine; dmap; (NH₂₄)SO₄; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; water;
DOI:10.1002/hlca.19970800313