((1S,2S)-1-Benzyloxymethyl-3-iodo-2-methyl-propoxy)-triisopropyl-silane

Base Information

Chemical Name:((1S,2S)-1-Benzyloxymethyl-3-iodo-2-methyl-propoxy)-triisopropyl-silane
CAS No.:503620-10-8
Molecular Formula:C₂₁H₃₇IO₂Si
Molecular Weight:476.514
Hs Code.:

Synonyms:((1S,2S)-1-Benzyloxymethyl-3-iodo-2-methyl-propoxy)-triisopropyl-silane

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Chemical Property of ((1S,2S)-1-Benzyloxymethyl-3-iodo-2-methyl-propoxy)-triisopropyl-silane

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Technology Process of ((1S,2S)-1-Benzyloxymethyl-3-iodo-2-methyl-propoxy)-triisopropyl-silane

There total 4 articles about ((1S,2S)-1-Benzyloxymethyl-3-iodo-2-methyl-propoxy)-triisopropyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 503620-09-5
4-benzyloxy-2-methyl-3-triisopropylsilanyloxy-butan-1-ol

: 503620-10-8
((1S,2S)-1-Benzyloxymethyl-3-iodo-2-methyl-propoxy)-triisopropyl-silane

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine; In diethyl ether; dichloromethane; at 23 ℃; for 2h;
DOI:10.1021/ja021385j

Reference yield:

: 60656-87-3
benzyloxyacetoaldehyde

: 503620-10-8
((1S,2S)-1-Benzyloxymethyl-3-iodo-2-methyl-propoxy)-triisopropyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1.1: TiCl₄; i-Pr₂NEt / CH₂Cl₂ / 0 - 23 °C

1.2: 93 percent / TiCl₄ / CH₂Cl₂ / 2 h / -78 °C

2.1: 95 percent / i-Pr₂NEt / 0 °C

3.1: 91 percent / Dibal-H / CH₂Cl₂ / 1 h / -40 °C

4.1: 90 percent / I₂; PPh₃; imidazole / diethyl ether; CH₂Cl₂ / 2 h / 23 °C

With 1H-imidazole; iodine; titanium tetrachloride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In diethyl ether; dichloromethane;
DOI:10.1021/ja021385j

Reference yield:

: 198962-85-5
4-benzyloxy-3-hydroxy-2-methyl-butyric acid 1-(toluene-4-sulfonylamino)-indan-2-yl ester

: 503620-10-8
((1S,2S)-1-Benzyloxymethyl-3-iodo-2-methyl-propoxy)-triisopropyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / i-Pr₂NEt / 0 °C

2: 91 percent / Dibal-H / CH₂Cl₂ / 1 h / -40 °C

3: 90 percent / I₂; PPh₃; imidazole / diethyl ether; CH₂Cl₂ / 2 h / 23 °C

With 1H-imidazole; iodine; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In diethyl ether; dichloromethane;
DOI:10.1021/ja021385j