(2S,3R,7R)-1-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-3-methyl-2-triisopropylsilanyloxy-decan-5-ol

Base Information

Chemical Name:(2S,3R,7R)-1-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-3-methyl-2-triisopropylsilanyloxy-decan-5-ol
CAS No.:503620-26-6
Molecular Formula:C₃₃H₆₄O₄Si₂
Molecular Weight:581.04
Hs Code.:

Synonyms:(2S,3R,7R)-1-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-3-methyl-2-triisopropylsilanyloxy-decan-5-ol

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Chemical Property of (2S,3R,7R)-1-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-3-methyl-2-triisopropylsilanyloxy-decan-5-ol

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Technology Process of (2S,3R,7R)-1-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-3-methyl-2-triisopropylsilanyloxy-decan-5-ol

There total 7 articles about (2S,3R,7R)-1-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-3-methyl-2-triisopropylsilanyloxy-decan-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 503620-11-9
(3R)-3-{[(tert-butyl)dimethylsilyl]oxy}hexanal

: 503620-10-8
((1S,2S)-1-Benzyloxymethyl-3-iodo-2-methyl-propoxy)-triisopropyl-silane

: 503620-26-6
(2S,3R,7R)-1-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-3-methyl-2-triisopropylsilanyloxy-decan-5-ol

Guidance literature:: ((1S,2S)-1-Benzyloxymethyl-3-iodo-2-methyl-propoxy)-triisopropyl-silane; With 4 A molecular sieve; tert.-butyl lithium; In diethyl ether; at -78 - 20 ℃;

(3R)-3-{[(tert-butyl)dimethylsilyl]oxy}hexanal; In diethyl ether; at -78 - 23 ℃; for 4h; Further stages.;
DOI:10.1021/ja021385j

Reference yield:

: 60656-87-3
benzyloxyacetoaldehyde

: 503620-26-6
(2S,3R,7R)-1-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-3-methyl-2-triisopropylsilanyloxy-decan-5-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: TiCl₄; i-Pr₂NEt / CH₂Cl₂ / 0 - 23 °C

1.2: 93 percent / TiCl₄ / CH₂Cl₂ / 2 h / -78 °C

2.1: 95 percent / i-Pr₂NEt / 0 °C

3.1: 91 percent / Dibal-H / CH₂Cl₂ / 1 h / -40 °C

4.1: 90 percent / I₂; PPh₃; imidazole / diethyl ether; CH₂Cl₂ / 2 h / 23 °C

5.1: t-BuLi; 4 Angstroem molecular sieves / diethyl ether / -78 - 20 °C

5.2: 80 percent / diethyl ether / 4 h / -78 - 23 °C

With 1H-imidazole; 4 A molecular sieve; iodine; tert.-butyl lithium; titanium tetrachloride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In diethyl ether; dichloromethane;
DOI:10.1021/ja021385j

Reference yield:

: 198962-85-5
4-benzyloxy-3-hydroxy-2-methyl-butyric acid 1-(toluene-4-sulfonylamino)-indan-2-yl ester

: 503620-26-6
(2S,3R,7R)-1-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-3-methyl-2-triisopropylsilanyloxy-decan-5-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / i-Pr₂NEt / 0 °C

2.1: 91 percent / Dibal-H / CH₂Cl₂ / 1 h / -40 °C

3.1: 90 percent / I₂; PPh₃; imidazole / diethyl ether; CH₂Cl₂ / 2 h / 23 °C

4.1: t-BuLi; 4 Angstroem molecular sieves / diethyl ether / -78 - 20 °C

4.2: 80 percent / diethyl ether / 4 h / -78 - 23 °C

With 1H-imidazole; 4 A molecular sieve; iodine; tert.-butyl lithium; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In diethyl ether; dichloromethane;
DOI:10.1021/ja021385j