benzoic acid (1R,3aR,4S,7aR)-1-[(S)-1'-methylpropyl]-7a-methyl-octahydro-inden-4-yl ester

Base Information

Chemical Name:benzoic acid (1R,3aR,4S,7aR)-1-[(S)-1'-methylpropyl]-7a-methyl-octahydro-inden-4-yl ester
CAS No.:952288-68-5
Molecular Formula:C₂₁H₃₀O₂
Molecular Weight:314.468
Hs Code.:

Synonyms:benzoic acid (1R,3aR,4S,7aR)-1-[(S)-1'-methylpropyl]-7a-methyl-octahydro-inden-4-yl ester

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Chemical Property of benzoic acid (1R,3aR,4S,7aR)-1-[(S)-1'-methylpropyl]-7a-methyl-octahydro-inden-4-yl ester

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Technology Process of benzoic acid (1R,3aR,4S,7aR)-1-[(S)-1'-methylpropyl]-7a-methyl-octahydro-inden-4-yl ester

There total 2 articles about benzoic acid (1R,3aR,4S,7aR)-1-[(S)-1'-methylpropyl]-7a-methyl-octahydro-inden-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 952288-67-4
benzoic acid (1R,3aR,4S,7aR)-7a-methyl-1-[(S)-1'-methylprop-2'-enyl]octahydro-inden-4-yl ester

: 952288-68-5
benzoic acid (1R,3aR,4S,7aR)-1-[(S)-1'-methylpropyl]-7a-methyl-octahydro-inden-4-yl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 20h;

Reference yield:

: 115527-12-3
(20R)-des-A,B-8β-(benzoyloxy)-23,24-dinorcholan-22-al

: 952288-68-5
benzoic acid (1R,3aR,4S,7aR)-1-[(S)-1'-methylpropyl]-7a-methyl-octahydro-inden-4-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0 - 20 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

With n-butyllithium; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; hexane; ethyl acetate; 1.2: Wittig reaction;
DOI:10.1021/jm200743p

Reference yield:

: 952288-68-5
benzoic acid (1R,3aR,4S,7aR)-1-[(S)-1'-methylpropyl]-7a-methyl-octahydro-inden-4-yl ester

: (20S)-1α-[(tert-butyldimethylsilyl)oxy]-2-[3'-[((tert-butyldimethylsilyl)oxy)propylidene]]-19,24,25,26,27-pentanorvitamin D3 tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; potassium hydroxide / methanol / 50 °C

2.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 20 °C / Molecular sieve

3.1: phenyllithium / tetrahydrofuran; dibutyl ether / -78 °C / Inert atmosphere

3.2: -78 - 6 °C / Inert atmosphere

With tetrapropylammonium perruthennate; water; phenyllithium; 4-methylmorpholine N-oxide; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; dibutyl ether; 3.2: Wittig-Horner coupling;
DOI:10.1021/jm200743p