115527-12-3Relevant articles and documents
2alpha-Methyl and 2beta-Methyl Analogs of 19,26-Dinor-1alpha,25-Dihydroxyvitamin D3 and Their Uses
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Page/Page column 8, (2012/11/13)
This invention discloses 2α-methyl and 2β-methyl analogs of 19,26-dinor-1α,25-dihydroxyvitamin D3 and pharmaceutical uses therefor. These compounds exhibit in vitro biological activities evidencing use as an anti-cancer agent and for the treatm
(20S,22E)-2-METHYLENE-19-NOR-22-ENE-1&α,25-DIHYDROXYVITAMIN D3 ANALOGS
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Page/Page column 12-13, (2011/04/25)
This invention discloses (20S.22E)-2-mcthylenc-19-nor-22-enc-1α,25- dihydroxyvitamin D3 analogs, and specifically(20S,22E)-2 -methylene- 19-nor-22-ene- 1 α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhib
2-METHYLENE-19,26-NOR-(20S)-1α-HYDROXYVITAMIN D3
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, (2011/06/23)
Compounds of formula I are provided where X1 and X2 are independently selected from H or hydroxy protecting groups. Such compounds may be used in preparing pharmaceutical compositions and are useful in treating a variety of biologica
Removal of the 26-methyl group from 19-nor-1α,25-dihydroxyvitamin D3 markedly reduces in vivo calcemic activity without altering in vitro VDR binding, HL-60 cell differentiation, and transcription
Grzywacz, Pawel,Chiellini, Grazia,Plum, Lori A.,Clagett-Dame, Margaret,Deluca, Hector F.
experimental part, p. 8642 - 8649 (2011/03/20)
Twelve new analogues of 19-nor-1α,25-dihydroxyvitamin D3 (5-16) were prepared by convergent syntheses, employing the Wittig Horner reaction. The necessary Grundmann type ketones (45-48), possessing fixed configurations of the hydroxyl group at
2-Methylene-19,26-Dinor-(20S,22E,25R)-Vitamin D Analogs
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Page/Page column 5-7, (2010/02/17)
This invention discloses 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs, and specifically 2-methylene-19,26-dinor-(20S,22E,25R)-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits transcription activity
2-Methylene-(20S,25R)-19,26-Dinor-Vitamin D Analogs
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Page/Page column 5-6; 8, (2009/07/17)
This invention discloses 2-methylene-(20S,25R)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25R)-19,26-dinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arrestin
2-Methylene-(20S,25S)-19,26-Dinor-Vitamin D Analogs
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Page/Page column 5-6; 8, (2009/07/17)
This invention discloses 2-methylene-(20S,25S)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25S)-19,26-dinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arrestin
2-Methylene-(20S,25S)-19,27-Dinor-(22E)-Vitamin D Analogs
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Page/Page column 5-6; 7, (2008/06/13)
This invention discloses 2-methylene-(20S,25S)-19,27-dinor-(22E)-vitamin D analogs, and specifically 2-methylene-(20S,25S)-19,27-dinor-(22E)-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity
2-alkylidene-18,19-dinor-vitamin D compounds
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Page/Page column 7-8, (2010/02/14)
2-alkylidene-18,19-dinor-vitamin D compounds are disclosed as well as pharmaceutical uses for these compounds and methods of synthesizing these compounds. These compounds are characterized by low bone calcium mobilization activity and high intestinal calc