(4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexanal

Base Information

Chemical Name:(4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexanal
CAS No.:1608457-84-6
Molecular Formula:C₃₉H₇₀O₃Si₂
Molecular Weight:643.154
Hs Code.:

Synonyms:(4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexanal

Suppliers and Price of (4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexanal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexanal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexanal

There total 5 articles about (4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1608457-83-5
(4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexanenitrile

: 1608457-84-6
(4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexanal

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; toluene; at -20 ℃; for 1h;
DOI:10.1021/jm500392t

Reference yield:

: 1608457-75-5
ethyl (3R)-4-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-3-ethylpentanoate

: 1608457-84-6
(4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexanal

Guidance literature:: Multi-step reaction with 4 steps

1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / 0 °C

2: pyridine / 37 h / 0 °C

3: dimethyl sulfoxide / 1.5 h / 70 °C

4: diisobutylaluminium hydride / toluene; dichloromethane / 1 h / -20 °C

With pyridine; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/jm500392t

Reference yield:

: 1237750-59-2
ethyl (2E)-4-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]pent-2-enoate

: 1608457-84-6
(4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexanal

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran; benzene; cyclohexane / 0.25 h / -30 °C

1.2: 1.5 h / -30 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / 0 °C

3.1: pyridine / 37 h / 0 °C

4.1: dimethyl sulfoxide / 1.5 h / 70 °C

5.1: diisobutylaluminium hydride / toluene; dichloromethane / 1 h / -20 °C

With pyridine; copper(I) bromide dimethylsulfide complex; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; cyclohexane; dimethyl sulfoxide; toluene; benzene;
DOI:10.1021/jm500392t