(4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexan-1-ol

Base Information

Chemical Name:(4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexan-1-ol
CAS No.:1608457-85-7
Molecular Formula:C₃₉H₇₂O₃Si₂
Molecular Weight:645.17
Hs Code.:

Synonyms:(4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexan-1-ol

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Chemical Property of (4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexan-1-ol

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Technology Process of (4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexan-1-ol

There total 6 articles about (4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1608457-84-6
(4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexanal

: 1608457-85-7
(4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexan-1-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; dichloromethane; at 0 - 20 ℃; for 1.5h;
DOI:10.1021/jm500392t

Reference yield:

: 1608457-75-5
ethyl (3R)-4-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-3-ethylpentanoate

: 1608457-85-7
(4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / 0 °C

2: pyridine / 37 h / 0 °C

3: dimethyl sulfoxide / 1.5 h / 70 °C

4: diisobutylaluminium hydride / toluene; dichloromethane / 1 h / -20 °C

5: sodium tetrahydroborate / methanol; dichloromethane / 1.5 h / 0 - 20 °C

With pyridine; sodium tetrahydroborate; diisobutylaluminium hydride; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/jm500392t

Reference yield:

: 1237750-59-2
ethyl (2E)-4-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]pent-2-enoate

: 1608457-85-7
(4R)-5-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]-4-ethylhexan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran; benzene; cyclohexane / 0.25 h / -30 °C

1.2: 1.5 h / -30 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / 0 °C

3.1: pyridine / 37 h / 0 °C

4.1: dimethyl sulfoxide / 1.5 h / 70 °C

5.1: diisobutylaluminium hydride / toluene; dichloromethane / 1 h / -20 °C

6.1: sodium tetrahydroborate / methanol; dichloromethane / 1.5 h / 0 - 20 °C

With pyridine; sodium tetrahydroborate; copper(I) bromide dimethylsulfide complex; diisobutylaluminium hydride; In tetrahydrofuran; methanol; dichloromethane; cyclohexane; dimethyl sulfoxide; toluene; benzene;
DOI:10.1021/jm500392t