tert-butyl 3-[5-(benzoyloxy)-4-(methoxycarbonyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]morpholine-4-carboxylate

Base Information

Chemical Name:tert-butyl 3-[5-(benzoyloxy)-4-(methoxycarbonyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]morpholine-4-carboxylate
CAS No.:518047-45-5
Molecular Formula:C₂₃H₂₇N₃O₈
Molecular Weight:473.483
Hs Code.:

Synonyms:tert-butyl 3-[5-(benzoyloxy)-4-(methoxycarbonyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]morpholine-4-carboxylate

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Chemical Property of tert-butyl 3-[5-(benzoyloxy)-4-(methoxycarbonyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]morpholine-4-carboxylate

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Technology Process of tert-butyl 3-[5-(benzoyloxy)-4-(methoxycarbonyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]morpholine-4-carboxylate

There total 1 articles about tert-butyl 3-[5-(benzoyloxy)-4-(methoxycarbonyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 518047-43-3
tert-butyl 3-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]morpholine-4-carboxylate

: 77-78-1
dimethyl sulfate

: 518047-45-5
tert-butyl 3-[5-(benzoyloxy)-4-(methoxycarbonyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]morpholine-4-carboxylate

: tert-butyl 3-[5-(benzoyloxy)-4-methoxy-6-(methoxycarbonyl)pyrimidin-2-yl]morpholine-4-carboxylate

Guidance literature:: tert-butyl 3-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]morpholine-4-carboxylate; With lithium hydride; In 1,4-dioxane; at 38 ℃; for 0.75h;

dimethyl sulfate; In 1,4-dioxane; at 20 - 56 ℃; for 8h; Further stages.;
DOI:10.1021/jm0704705

Reference yield: 68.0%

: 518047-45-5
tert-butyl 3-[5-(benzoyloxy)-4-(methoxycarbonyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]morpholine-4-carboxylate

: 140-75-0
para-fluorobenzylamine

: 518047-46-6
tert-butyl 3-(4-{[(4-fluorobenzyl)amino]carbonyl}-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)morpholine-4-carboxylate

Guidance literature:: In methanol; for 2h; Heating;
DOI:10.1021/jm0704705

Reference yield:

: 518047-45-5
tert-butyl 3-[5-(benzoyloxy)-4-(methoxycarbonyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]morpholine-4-carboxylate

: 108-24-7
acetic anhydride

: 140-75-0
para-fluorobenzylamine

: C₁₉H₂₁FN₄O₅

Guidance literature:: tert-butyl 3-[5-(benzoyloxy)-4-(methoxycarbonyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]morpholine-4-carboxylate; With trifluoroacetic acid; In dichloromethane; water; at 20 ℃; for 0.5h;

acetic anhydride; In pyridine; at 20 ℃;

para-fluorobenzylamine; In methanol; Further stages.; Heating;
DOI:10.1021/jm0704705