tert-butyl 3-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]morpholine-4-carboxylate

Base Information

• Chemical Name: tert-butyl 3-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]morpholine-4-carboxylate
• CAS No.: 518047-43-3
• Molecular Formula: C₂₂H₂₅N₃O₈
• Molecular Weight: 459.456
• Mol file: 518047-43-3.mol

Synonyms:tert-butyl 3-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]morpholine-4-carboxylate

Chemical Property of tert-butyl 3-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]morpholine-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 3-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]morpholine-4-carboxylate

There total 2 articles about tert-butyl 3-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-[amino(hydroxyimino)methyl]morpholine-4-carboxylate (518058-62-3,519031-82-4) → tert-butyl 3-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]morpholine-4-carboxylate (518047-43-3)

Guidance literature:

Multi-step reaction with 2 steps

1: CHCl₃ / 3 h / Heating

2: pyridine / 20 °C

With pyridine; In chloroform;

DOI:10.1021/jm060854f

Reference yield:

dimethyl acetylenedicarboxylate (762-42-5) → tert-butyl 3-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]morpholine-4-carboxylate (518047-43-3)

Guidance literature:

Multi-step reaction with 2 steps

1: CHCl₃ / 3 h / Heating

2: pyridine / 20 °C

With pyridine; In chloroform;

DOI:10.1021/jm060854f

Reference yield: 64.0%

tert-butyl 3-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]morpholine-4-carboxylate (518047-43-3) + dimethyl sulfate (77-78-1) → tert-butyl 3-[5-(benzoyloxy)-4-(methoxycarbonyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]morpholine-4-carboxylate (518047-45-5) + tert-butyl 3-[5-(benzoyloxy)-4-methoxy-6-(methoxycarbonyl)pyrimidin-2-yl]morpholine-4-carboxylate

Guidance literature:

tert-butyl 3-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]morpholine-4-carboxylate; With lithium hydride; In 1,4-dioxane; at 38 ℃; for 0.75h;

dimethyl sulfate; In 1,4-dioxane; at 20 - 56 ℃; for 8h; Further stages.;

DOI:10.1021/jm0704705

upstream raw materials:

tert-butyl 3-[amino(hydroxyimino)methyl]morpholine-4-carboxylate

dimethyl acetylenedicarboxylate

Downstream raw materials:

tert-butyl 3-[5-(benzoyloxy)-4-(methoxycarbonyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]morpholine-4-carboxylate