N-((1S,2R)-2-Hydroxy-1-isobutyl-but-3-enyl)-4-methyl-benzenesulfonamide

Base Information

Chemical Name:N-((1S,2R)-2-Hydroxy-1-isobutyl-but-3-enyl)-4-methyl-benzenesulfonamide
CAS No.:132065-46-4
Molecular Formula:C₁₅H₂₃NO₃S
Molecular Weight:297.419
Hs Code.:

Synonyms:N-((1S,2R)-2-Hydroxy-1-isobutyl-but-3-enyl)-4-methyl-benzenesulfonamide

Suppliers and Price of N-((1S,2R)-2-Hydroxy-1-isobutyl-but-3-enyl)-4-methyl-benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((1S,2R)-2-Hydroxy-1-isobutyl-but-3-enyl)-4-methyl-benzenesulfonamide

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Technology Process of N-((1S,2R)-2-Hydroxy-1-isobutyl-but-3-enyl)-4-methyl-benzenesulfonamide

There total 11 articles about N-((1S,2R)-2-Hydroxy-1-isobutyl-but-3-enyl)-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 187532-15-6
(4S,5R)-N-(4-methylbenzenesulfonyl)-4-(2-methylpropyl)-5-vinyloxazolidin-2-one

: 132065-46-4
N-((1S,2R)-2-Hydroxy-1-isobutyl-but-3-enyl)-4-methyl-benzenesulfonamide

Guidance literature:: With potassium hydroxide; In methanol; water; for 2h; Heating;
DOI:10.1021/jo961760o

Reference yield: 81.0%

: 117248-23-4,132065-38-4
(3RS,4S)-4-amino-6-methylhept-1-en-3-ol

: 98-59-9
p-toluenesulfonyl chloride

: 132065-46-4,132065-52-2
(3RS,4S)-6-methyl-4-(p-tolylsulfonylamino)hept-1-en-3-ol

Guidance literature:: With triethylamine; In tetrahydrofuran; water; 1.) 0 deg C, 30 min, 2.) room temperature, overnight;

Reference yield:

: 7533-40-6,14438-11-0
(S)-2-amino-4-methylpentan-1-ol

: 132065-46-4
N-((1S,2R)-2-Hydroxy-1-isobutyl-but-3-enyl)-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / Et₃N / dimethylformamide / 18 h / 0 °C

2: 1.) oxalyl chloride, DMSO, 2.) diisopropylethylamine / 1) CH₂Cl₂, -78 deg C, 1 h; 2) CH₂Cl₂, -78 --> 0 deg C, 2 h

3: 74 percent / ZnCl₂ / tetrahydrofuran / 1 h / -78 - 0 °C

4: 13 percent / NaH / tetrahydrofuran; dimethylformamide / 18 h / Ambient temperature

5: 85 percent / NaH / tetrahydrofuran; dimethylformamide / 18 h / Ambient temperature

6: 97 percent / KOH / methanol; H₂O / 2 h / Heating

With potassium hydroxide; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; zinc(II) chloride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo961760o