9-(2-acetyl-3-azido-3-deoxy-5-O-toluoyl-β-D-ribofuranosyl)-2-amino-6-chloropurine

Base Information

Chemical Name:9-(2-acetyl-3-azido-3-deoxy-5-O-toluoyl-β-D-ribofuranosyl)-2-amino-6-chloropurine
CAS No.:879398-57-9
Molecular Formula:C₂₀H₁₉ClN₈O₅
Molecular Weight:486.874
Hs Code.:

Synonyms:9-(2-acetyl-3-azido-3-deoxy-5-O-toluoyl-β-D-ribofuranosyl)-2-amino-6-chloropurine

Suppliers and Price of 9-(2-acetyl-3-azido-3-deoxy-5-O-toluoyl-β-D-ribofuranosyl)-2-amino-6-chloropurine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 9-(2-acetyl-3-azido-3-deoxy-5-O-toluoyl-β-D-ribofuranosyl)-2-amino-6-chloropurine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 9-(2-acetyl-3-azido-3-deoxy-5-O-toluoyl-β-D-ribofuranosyl)-2-amino-6-chloropurine

There total 1 articles about 9-(2-acetyl-3-azido-3-deoxy-5-O-toluoyl-β-D-ribofuranosyl)-2-amino-6-chloropurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 3-azido-3-deoxy-1,2-di-O-acetyl-5-O-toluoyl-α-D-ribofuranose

: 10310-21-1
2-Amino-6-chloropurin

: 879398-57-9
9-(2-acetyl-3-azido-3-deoxy-5-O-toluoyl-β-D-ribofuranosyl)-2-amino-6-chloropurine

Guidance literature:: With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 80 ℃; for 3h;
DOI:10.1016/j.bmc.2005.09.062

Reference yield: 81.0%

: 879398-57-9
9-(2-acetyl-3-azido-3-deoxy-5-O-toluoyl-β-D-ribofuranosyl)-2-amino-6-chloropurine

: 879398-58-0
9-(2-acetyl-3-azido-3-deoxy-5-O-toluoyl-β-D-ribofuranosyl)-6-chloro-2-iodopurine

Guidance literature:: With diiodomethane; iodine; isopentyl nitrite; copper(l) iodide; In tetrahydrofuran; for 0.75h; Heating;
DOI:10.1016/j.bmc.2005.09.062

Reference yield:

: 879398-57-9
9-(2-acetyl-3-azido-3-deoxy-5-O-toluoyl-β-D-ribofuranosyl)-2-amino-6-chloropurine

: 9-(3-amino-3-deoxy-β-D-ribofuranosyl)-N⁶-methyl-2-phenylethynyladenine

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / isoamyl nitrite; I₂; CH₂I₂ / CuI / tetrahydrofuran / 0.75 h / Heating

2: triethylamine / ethanol / Heating

3: 127 mg / ammonia / methanol / 2 h / 20 °C

4: 95 percent / Na / methanol / 1 h / 20 °C

5: 92 percent / triphenylphosphine / tetrahydrofuran; H₂O / 48 h

6: 81 percent / triethylamine; CuI / (PPh₃)2PdCl₂ / dimethylformamide / 3 h / 20 °C

With copper(l) iodide; diiodomethane; ammonia; iodine; sodium; triethylamine; triphenylphosphine; isopentyl nitrite; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; 6: Sonogashira coupling;
DOI:10.1016/j.bmc.2005.09.062