4-HYDROXY-1,3-DIMETHYL-1H-QUINOLIN-2-ONE

Base Information

• Chemical Name: 4-HYDROXY-1,3-DIMETHYL-1H-QUINOLIN-2-ONE
• CAS No.: 32606-02-3
• Molecular Formula: C11H11 N O2
• Molecular Weight: 189.214
• Hs Code.: 2933790090
• Mol file: 32606-02-3.mol

Synonyms:Carbostyril,4-hydroxy-1,3-dimethyl- (6CI,7CI,8CI); 1,3-Dimethyl-4-hydroxy-2-quinolone;4-Hydroxy-1,3-dimethyl-2(1H)-quinolinone; NSC 193539

Chemical Property of 4-HYDROXY-1,3-DIMETHYL-1H-QUINOLIN-2-ONE

Chemical Property:

• Vapor Pressure: 0.000437mmHg at 25°C
• Boiling Point: 302.4°Cat760mmHg
• Flash Point: 136.7°C
• PSA: 42.23000
• Density: 1.26g/cm³
• LogP: 1.55250

Purity/Quality:

4-HYDROXY-1,3-DIMETHYL-1H-QUINOLIN-2-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXY-1,3-DIMETHYL-1H-QUINOLIN-2-ONE

There total 20 articles about 4-HYDROXY-1,3-DIMETHYL-1H-QUINOLIN-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-(azidomethyl)-1,3-dimethylquinoline-2,4(1H,3H)-dione → 4-hydroxy-1,3-dimethyl-2(1H)-quinolone (32606-02-3)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; water; at 20 ℃; for 2h;

DOI:10.1002/adsc.202100208

Reference yield: 86.0%

N-methylanthraniloyl-coenzyme A + (2RS)-methylmalonyl-CoA (1264-45-5,10251-08-8,73173-91-8,73173-92-9) → 4-hydroxy-1,3-dimethyl-2(1H)-quinolone (32606-02-3)

Guidance literature:

With potassium phosphate buffer; ethylenediaminetetraacetic acid; at 30 ℃; for 12h; pH=8.0;

DOI:10.1021/ol0625233

Reference yield: 63.0%

1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxoquinolin-3-yl thiocyanate (1399323-83-1) → 4-hydroxy-1,3-dimethyl-2(1H)-quinolone (32606-02-3) + 3a5-dimethyl[1,3]thiazolo[5,4-c]quinoline-2,4(3aH,5H)-dione (1399324-32-3) + 5,9b-dihydro-9b-hydroxy-3a-,5-dimethyl[1,3]thiazolo[5,4-c]quinoline-2,4(1H,3aH)-dione (1399324-73-2)

Guidance literature:

With phosphorus pentoxide; sulfuric acid; acetic acid; at 20 ℃; for 2.5h;

DOI:10.1002/hlca.201200049

upstream raw materials:

4-amino-1,3-dimethylquinolin-2(1H)-one

2-Methyl-3-(2-methylamino-phenyl)-3-oxo-propionic acid ethyl ester

methanol

N-methylaniline

Downstream raw materials:

2-N-methylaminophenyl isopropyl ketone

4-amino-1,3-dimethylquinolin-2(1H)-one

4-Benzylamino-1,3-dimethyl-1H-quinolin-2-one

N-methylflindersine