(E)-N-(4-methoxyphenyl)-3-(4-(trifluoromethyl)phenyl)acrylamide

Base Information

• Chemical Name: (E)-N-(4-methoxyphenyl)-3-(4-(trifluoromethyl)phenyl)acrylamide
• CAS No.: 1003444-36-7
• Molecular Formula: C₁₇H₁₄F₃NO₂
• Molecular Weight: 321.299
• Mol file: 1003444-36-7.mol

Synonyms:(E)-N-(4-methoxyphenyl)-3-(4-(trifluoromethyl)phenyl)acrylamide

Chemical Property of (E)-N-(4-methoxyphenyl)-3-(4-(trifluoromethyl)phenyl)acrylamide

Chemical Property:

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Technology Process of (E)-N-(4-methoxyphenyl)-3-(4-(trifluoromethyl)phenyl)acrylamide

There total 1 articles about (E)-N-(4-methoxyphenyl)-3-(4-(trifluoromethyl)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-<4'-(trifluoromethyl)phenyl>-2-propenoic acid (2062-26-2,87212-84-8,16642-92-5) + 4-methoxy-aniline (104-94-9) → (E)-N-(4-methoxyphenyl)-3-(4-(trifluoromethyl)phenyl)acrylamide (1003444-36-7)

Guidance literature:

With tris(2,2,2-trifluoroethyl) borate; In acetonitrile; at 80 ℃; for 15h;

DOI:10.1039/c0ob01069c

Reference yield: 51.0%

(E)-N-(4-methoxyphenyl)-3-(4-(trifluoromethyl)phenyl)acrylamide (1003444-36-7) + (2-phenylquinoline(1-))2Ir(μ-Cl)2Ir(2-phenylquinoline)2 → (2-phenylquinoline(1-))2Ir((E)-N-(4-methoxyphenyl)-3-(4-(trifluoromethyl)phenyl)acrylamide(1-))

Guidance literature:

With sodium methylate; In dichloromethane; at 20 ℃; for 48h; Inert atmosphere; Schlenk technique;

DOI:10.1021/om400275m

upstream raw materials:

3-<4'-(trifluoromethyl)phenyl>-2-propenoic acid

4-methoxy-aniline