Technology Process of C18H12BrN3O2
There total 7 articles about C18H12BrN3O2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylamine;
In
toluene;
at 0 ℃;
for 12.45h;
Inert atmosphere;
Reflux;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium hydroxide / ethanol; water / 2 h / Reflux
2: triethylamine; diphenyl phosphoryl azide / 12 h / Reflux
3: trifluoroacetic acid / dichloromethane / 8 h / 0 - 20 °C
4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere
5: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C
6: triethylamine / toluene / 12.45 h / 0 °C / Inert atmosphere; Reflux
With
diphenyl phosphoryl azide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium hydroxide;
In
ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C
2: triethylamine / toluene / 12.45 h / 0 °C / Inert atmosphere; Reflux
With
triethylamine; trifluoroacetic acid;
In
dichloromethane; toluene;
