(S)-2-(Biphenyl-3-ylamino)-4-methyl-pentanoic acid {(S)-1-[(4-cyanomethoxy-phenylamino)-methyl]-propyl}-amide

Base Information

Chemical Name:(S)-2-(Biphenyl-3-ylamino)-4-methyl-pentanoic acid {(S)-1-[(4-cyanomethoxy-phenylamino)-methyl]-propyl}-amide
CAS No.:757975-85-2
Molecular Formula:C₃₀H₃₆N₄O₂
Molecular Weight:484.641
Hs Code.:

Synonyms:(S)-2-(Biphenyl-3-ylamino)-4-methyl-pentanoic acid {(S)-1-[(4-cyanomethoxy-phenylamino)-methyl]-propyl}-amide

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Chemical Property of (S)-2-(Biphenyl-3-ylamino)-4-methyl-pentanoic acid {(S)-1-[(4-cyanomethoxy-phenylamino)-methyl]-propyl}-amide

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Technology Process of (S)-2-(Biphenyl-3-ylamino)-4-methyl-pentanoic acid {(S)-1-[(4-cyanomethoxy-phenylamino)-methyl]-propyl}-amide

There total 11 articles about (S)-2-(Biphenyl-3-ylamino)-4-methyl-pentanoic acid {(S)-1-[(4-cyanomethoxy-phenylamino)-methyl]-propyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 757976-48-0
N²-(biphenyl-3-yl)-N-((1S)-1-{[(4-hydroxyphenyl)amino]methyl}propyl)-N²-(biphenyl-3-yl)-L-leucinamide

: 590-17-0
cyanomethyl bromide

: 757975-85-2
(S)-2-(Biphenyl-3-ylamino)-4-methyl-pentanoic acid {(S)-1-[(4-cyanomethoxy-phenylamino)-methyl]-propyl}-amide

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.12.053

Reference yield:

: 757976-17-3
N-(biphenyl-3-yl)-L-leucine

: 757975-85-2
(S)-2-(Biphenyl-3-ylamino)-4-methyl-pentanoic acid {(S)-1-[(4-cyanomethoxy-phenylamino)-methyl]-propyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / CH₂Cl₂

1.2: 99 percent / 1-hydroxybenzotriazole; 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide HCl / dimethylformamide

2.1: 87 percent / H₂ / Pd-C / ethanol / 6 h / 40 °C

3.1: 59 percent / NaH / tetrahydrofuran; dimethylformamide / 0 - 20 °C

With hydrogen; sodium hydride; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 1.2: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.06.032

Reference yield:

: 757976-46-8
tert-butyl [(1S)-1-({[4-(benzyloxy)phenyl]amino}methyl)propyl]carbamate

: 757975-85-2
(S)-2-(Biphenyl-3-ylamino)-4-methyl-pentanoic acid {(S)-1-[(4-cyanomethoxy-phenylamino)-methyl]-propyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / CH₂Cl₂

1.2: 99 percent / 1-hydroxybenzotriazole; 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide HCl / dimethylformamide

2.1: 87 percent / H₂ / Pd-C / ethanol / 6 h / 40 °C

3.1: 59 percent / NaH / tetrahydrofuran; dimethylformamide / 0 - 20 °C

With hydrogen; sodium hydride; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 1.2: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.06.032