N-(9-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Base Information

Chemical Name:N-(9-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide
CAS No.:175355-15-4
Molecular Formula:C₅₃H₅₁N₇O₇
Molecular Weight:898.031
Hs Code.:

N-(9-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Synonyms:N-(9-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

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Chemical Property of N-(9-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

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Technology Process of N-(9-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

There total 5 articles about N-(9-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 98-88-4
benzoyl chloride

: 1053652-95-1
(2R,3R,4R,5R)-5-(6-Amino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butoxy]-tetrahydro-furan-3-ol

: 175355-15-4
N-(9-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: With chloro-trimethyl-silane; In pyridine; for 3h; Ambient temperature;
DOI:10.1021/jo9518213

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 175355-15-4
N-(9-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / Et₃N / pyridine / 6 h / Ambient temperature

2: 27 percent / Me₃SiCl / pyridine / 3 h / Ambient temperature

With chloro-trimethyl-silane; triethylamine; In pyridine;
DOI:10.1021/jo9518213

Reference yield:

: 115008-03-2
4-(4-bromobutyl)-4’-methyl-2,2’-bipyridine

: 175355-15-4
N-(9-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 2 steps

2: 27 percent / Me₃SiCl / pyridine / 3 h / Ambient temperature

With chloro-trimethyl-silane; In pyridine;
DOI:10.1021/jo9518213